Olsalazine sodium

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Olsalazine sodium
Olsalazine sodium (Dipentum)
Olsalazine Sodium
(ohl- SAL-ah-zeen)
Pregnancy Category: C Dipentum (Rx)

Classification: Anti-inflammatory drug

Action/Kinetics: A salicylate that is converted by bacteria in the colon to 5-PAS (5-para-aminosalicylate), which exerts an anti-inflammatory effect for the treatment of ulcerative colitis. 5-PAS is slowly absorbed resulting in a high concentration of drug in the colon. The anti-inflammatory activity is likely due to inhibition of synthesis of prostaglandins in the colon. After PO use the drug is only slightly absorbed (2.4%) into systemic circulation where it has a short half-life ( < 1 hr) and is more than 99% bound to plasma proteins.

Uses: To maintain remission of ulcerative colitis in clients who cannot take sulfasalazine.

Contraindications: Hypersensitivity to salicylates.

Special Concerns: Use with caution during lactation. Safety and efficacy have not been established in children. May cause worsening of symptoms of colitis.

Side Effects: GI: Diarrhea (common), pain or cramps, nausea, dyspepsia, bloating, anorexia, vomiting, stomatitis. CNS: Headache, drowsiness, lethargy, fatigue, dizziness, vertigo. Miscellaneous: Arthralgia, rash, itching, upper respiratory tract infection. NOTE: The following symptoms have been reported on withdrawal of therapy: diarrhea, nausea, abdominal pain, rash, itching, headache, heartburn, insomnia, anorexia, dizziness, lightheadedness, rectal bleeding, depression.

Overdose Management: Symptoms: Diarrhea, decreased motor activity. Treatment: Treat symptoms.

How Supplied: Capsule: 250 mg

Adults: Total of 1 g/day in two divided doses.

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