Nortriptyline hydrochloride

Questions | Reviews **~

Will Nortriptyline effect my liver?

I have been diagnosed with lupus and auto-immune hepatitis and am being tested for fibromyalgia. Will this drug have negative effects on my liver and are there any other drugs in this class that I could consider to treat lupus?
by Nancy de Blauw in Innisfil, ON., Canada, 12/16/2005

Nortriptyline hydrochloride
Nortriptyline hydrochloride (Aventyl)
Nortriptyline hydrochloride
(nor- TRIP-tih-leen)
Pregnancy Category: C Apo-Nortriptyline Aventyl Gen-Nortriptyline Norventyl Novo-Nortriptyline Nu-Nortriptyline PMS-Nortriptyline Pamelor (Rx)

Classification: Antidepressant, tricyclic

See Also: See also Antidepressants, Tricyclic .

Action/Kinetics: Manifests moderate anticholinergic and sedative effects but slight orthostatic hypotensive effects. Effective plasma levels: 50-150 ng/mL. t 1/2: 18-44 hr. Time to reach steady state: 4-19 days.

Uses: Treatment of symptoms of depression. Chronic, severe neurogenic pain. Dermatologic disorders including chronic urticaria, angioedema, and nocturnal pruritus in atopic eczema.

Contraindications: Use in children (safety and efficacy have not been determined).

Laboratory Test Alterations: Urinary 5-HIAA.

How Supplied: Capsule: 10 mg, 25 mg, 50 mg, 75 mg; Solution: 10 mg base/5 mL

?Capsules, Oral Solution Depression.
Adults: 25 mg t.i.d.-q.i.d. Dose individualized; begin at a low dosage and increase as needed. Doses above 150 mg/day are not recommended. Adolescent and elderly clients: 30-50 mg/day in divided doses or total daily dose may be given once/day.
Dermatologic disorders.
75 mg/day.

Nortriptyline hydrochloride Ratings

Overall Rating:



(based on 4 reviews)



Ease of Use:


Overall Satisfaction:




Nortriptyline hydrochloride

Effectiveness: **

Ease of Use: **

Overall Satisfaction: ****


Areej, Areej - 01/13/2014

I have had one constant hedhcaae for 32 years now. I had meningitis when I wax 15 and have been left with a debilitating hedhcaae day and night ever since. Nothing makes it better and nothing makes it worse. It doesn't change with light sound stress happiness. It wakes me up every night. Like the guy in this story I have had numerous medications for prevention over the years including mirtazapinr and topomax(topiromate) which gave some relief for a good few months but when I came off that combo it was back to the bad old days. When I tried to restart the combo it didnt work any more which i believe is quite common. I I have tried every alternative therapy privately and through the pain clinic. There isn't a tablet that I haven't tried. I'm currently on no prevention meds but need morphine dihydrocodeine and naproxen antiflamitory plus a new med suggested by my hedhcaae specialist neurologist: methysergide ( deseril). I am finding this better than triptans but it can cause internal scar tissue round organs like heart so can only be taken 5 months at a time then a break of a month or two. Had occipital nerve blocks and they didn't work. Had test for hemicrania continua (indomethacin trial) with negative response. Had high dose intravemous steroid therapy felt awful and didnt work. Currently waiting for dihydroergotomone infusions in hospital for a week to give temporary relief from pain and to try to detox from morphine. Also waiting to have Botox treatment when it becomes available on NHS in Scotland in April/May 2013. Not holding out much hope but if it improves severity and frequency then quality of life will be better. I'm holding down a full time job out if sheer stubbornness as I don't want this hedhcaae to steal my life.I'm too young to be a zombie lying on the couch on agony everh day feeling sorry for myself. I have attended a neurologist for the past 6 years and when she came to the end of the road with treatments to offer me I was referred to a hedhcaae specialist 1.5 years ago. It was this doctor who gave me my diagnosis of NDPH. It was such a relief to have some affirmation that this was not a bad/long term migraine which I'd been telling everyone for years that it wasn't and that it wasn't a rebound hedhcaae ( which every doctor and my now separated husband have been telling me for years). It also felt like a life sentence because NDPH Ldoes not respond to treatment or meds. Up until my diagnosis I had been holding onto hope that perhaps after the menopause or when I was older I would have a better pain free life. Now I have had to come to terms with the fact that this is my life and it won't be changing ever. I'm not giving in though. I am fighting for my rights to keep being offered something else. I know I won't be cured but I am looking for just a little bit better quality of life. Relief for a couple of hours each day would be great even better would be one day pain free each week. Who knows. It's such a help reading your stories and comments to know that someone out there knows what it's like to be me. My old neurologist told my husband on the phone that your wife is a drug addict. The only reason she had hedhcaaes is because she needs her next fix. When she is off all meds she will have no hedhcaae . Incidentally I have been off all pain meds 3 times in the past 6 years and the hedhcaae had been unchanged every time. My husband went from being my biggest supporter to jumping on the rebound hedhcaae band wagon. I'm afraid it was the straw the broke the camels back and now we've bend separated for 5 months. It's such a shame. Now I'm facing a lonely life on my own starting from the beginning again and coping with this constant pain the best I can.

Nortriptyline hydrochloride

Effectiveness: *

Ease of Use: *

Overall Satisfaction: *


matinah, Willcox, Arizona - 10/19/2009

I was prescribed Nortriptyline for nerve pain, which interrupted my sleep. Instead, it kept me awake because of anxiety and nervousness, which were new symptoms for me.

Nortriptyline hydrochloride

Effectiveness: ****

Ease of Use: ****

Overall Satisfaction: ****


K.V.Shriram, sacormento cal - 01/19/2008

I take this everynight to help my feet feel better, and it works great. Is this medication also used to treat depression?