Nortriptyline hydrochloride Dosage, Interactions, Side Effects, How to Use

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Will Nortriptyline effect my liver? I have been diagnosed with lupus and auto-immune hepatitis and am being tested for fibromyalgia. Will this drug have negative effects on my liver and are there any other drugs in this class that I could consider to treat lupus? by Nancy de Blauw in Innisfil, ON., Canada, 12/16/2005

Nortriptyline hydrochloride
Nortriptyline hydrochloride (Aventyl)
Nortriptyline hydrochloride
(nor- TRIP-tih-leen)
Pregnancy Category: C Apo-Nortriptyline Aventyl Gen-Nortriptyline Norventyl Novo-Nortriptyline Nu-Nortriptyline PMS-Nortriptyline Pamelor (Rx)

Classification: Antidepressant, tricyclic

See Also: See also Antidepressants, Tricyclic .

Action/Kinetics: Manifests moderate anticholinergic and sedative effects but slight orthostatic hypotensive effects. Effective plasma levels: 50-150 ng/mL. t 1/2: 18-44 hr. Time to reach steady state: 4-19 days.

Uses: Treatment of symptoms of depression. Chronic, severe neurogenic pain. Dermatologic disorders including chronic urticaria, angioedema, and nocturnal pruritus in atopic eczema.

Contraindications: Use in children (safety and efficacy have not been determined).

Laboratory Test Alterations: Urinary 5-HIAA.

How Supplied: Capsule: 10 mg, 25 mg, 50 mg, 75 mg; Solution: 10 mg base/5 mL

Dosage
?Capsules, Oral Solution Depression.
Adults: 25 mg t.i.d.-q.i.d. Dose individualized; begin at a low dosage and increase as needed. Doses above 150 mg/day are not recommended. Adolescent and elderly clients: 30-50 mg/day in divided doses or total daily dose may be given once/day.
Dermatologic disorders.
75 mg/day.