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Nitroglycerin transdermal system Dosage, Interactions, Side Effects, How to Use

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Comparision of transdermal nitro at 0.4 mg/hr vs 60 mg isorbide mononitrate  Patients was on Nitro transdermal patch at 0.4 mg/hr and substitution was made with isobide mononitrate, 60 mg qd. Is there equivalence or the pill less effective than the patch.   M. Keith Nadel, MD, PhD. by Dr. M. Keith Nadel, MD, PhD in Ocala, FL, 10/23/2009

Is there a transdermal patch for sensitive skin? Is there a Nitroglyserin transdermal patch with adhesive for sensitive skin? by Fred Hintze in NC, 12/28/2007

Nitroglycerin transdermal system
Nitroglycerin transdermal system (Deponit 0.2 mg/hr and 0.4 mg/hr)
Nitroglycerin Transdermal System
(nye-troh- GLIH-sir-in)
Pregnancy Category: C Deponit 0.2 mg/hr and 0.4 mg/hr Minitran 0.1 mg/hr, 0.2 mg/hr, 0.4 mg/hr, and 0.6 mg/hr Nitrek 0.2 mg/hr, 0.4 mg/hr, and 0.6 mg/hr Nitrodisc 0.2 mg/hr, 0.3 mg/hr, and 0.4 mg/hr Nitro-Dur 0.1 mg/hr, 0.2 mg/hr, 0.3 mg/hr, 0.4 mg/hr, 0.6 mg/hr, and 0.8 mg/hr Transderm-Nitro 0.1 mg/hr, 0.2 mg/hr, 0.4 mg/hr, and 0.6 mg/hr (Rx)

Classification: Antianginal agent (coronary vasodilator)

See Also: See also Antianginal Drugs, Nitrates/Nitrites .

Action/Kinetics: Onset: 30-60 min; duration: 8-24 hr. The amount released each hour is indicated in the name.

Uses: Prophylaxis of angina pectoris due to CAD. NOTE: There is some evidence that nitroglycerin patches stop preterm labor. Also, high-dose nitrate therapy with an ACE inhibitor may cause significant, progressive, and long-term enhancement of exercise tolerance within 2 months of initiation of nitrate therapy.

Special Concerns: Dosage has not been established in children.

How Supplied: Film, Extended Release: 0.1 mg/hr, 0.2 mg/hr, 0.3 mg/hr, 0.4 mg/hr, 0.6 mg/hr, 0.8 mg/hr

Dosage
?Topical Patch
Initial: 0.2-0.4 mg/hr (initially the smallest available dose in the dosage series) applied each day to skin site free of hair and free of excessive movement (e.g., chest, upper arm). Maintenance: Additional systems or strengths may be added depending on the clinical response.