Niacin Dosage, Interactions, Side Effects, How to Use
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Does Niacin effect an alcohol drug test? I need to know if Niacin effects the results of an alcohol drug test? I read on the internet that it retains alcohol in your system. by Stephanie in Sarasota, Florida, 02/07/2008
Can Niacin 500mg be taken with Ibuprofen? Can you take Niacin 500mg be taken with Ibuprofen? If you have the side effects of itching skin what should you do? by Marla Lopez in Thibodaux,LA, 09/29/2006
Hot facial flushing I am a 72 year old male. The past 5 weeks I have been having facial flushing constantly with no other symptoms. My BP is 115/75 and I am otherwise very healthy. I take a multivitamin every morning that contains 20mg Niacin. I have been taking this vit... by jom fabruzzi in Rhode Island USA, 09/25/2006
Niacin with a Cirrotic Patient I have had hepC for approxamitly 30 years and diagnoised with Cirrhosis 6 years ago, during gallbladder removal, Pos A B antibodies. I was not and am not now a candidate for therapy because of major depression, and a co-morbid condition possible found... by JIM in Stuart, FL, 06/06/2006
Effects of Niacin during pregnancy What are the effects of Niacin on a fetus when taken on a regular basis during pregnancy. Are there any long term effects. by jbuckdenny in Petersburg, Virginia, 04/12/2006
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Classification:
Vitamin B complex
Action/Kinetics:
Niacin (nicotinic acid) and niacinamide are water-soluble, heat-resistant vitamins prepared synthetically. Niacin (after conversion to the active niacinamide) is a component of the coenzymes nicotinamide-adenine dinucleotide and nicotinamide-adenine dinucleotide phosphate, which are essential for oxidation-reduction reactions involved in lipid metabolism, glycogenolysis, and tissue respiration. Deficiency of niacin results in pellagra, the most common symptoms of which are dermatitis, diarrhea, and dementia. In high doses niacin also produces vasodilation. Reduces serum cholesterol and triglycerides in types II, III, IV, and V hyperlipoproteinemia (mechanism unknown).
Peak serum levels: 45 min;
t
1/2: 45 min.
Uses:
Prophylaxis and treatment of pellagra; niacin deficiency. Treat hyperlipidemia in clients not responding to either diet or weight loss. Reduce the risk of recurrent nonfatal MI in those with a history of MI and hypercholoesterolemia. Promote regression of atherosclerosis when combined with bile-binding resins. Niaspan is approved for increasing HDL cholesterol in dyslipidemia.
Contraindications:
Severe hypotension, hemorrhage, arterial bleeding, liver dysfunction, active peptic ulcer. Use of the extended-release tablets and capsules in children.
Special Concerns:
Extended-release niacin may be hepatotoxic. Use with caution in diabetics, gall bladder disease, in those who consume a large amount of alcohol, and clients with gout.
Side Effects:
GI: N&V, diarrhea, peptic ulcer activation, abdominal pain.
Dermatologic: Flushing, warm feeling, skin rash, pruritus, dry skin, itching and tingling feeling, keratosis nigricans.
Other: Hypotension, headache, macular cystoid edema, amblyopia.
NOTE: Megadoses are accompanied by serious toxicity including the symptoms listed in the preceding as well as liver damage, hyperglycemia, hyperuricemia, arrhythmias, tachycardia, and dermatoses.
Drug Interactions:
How Supplied:
Dosage
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(Rx: Injection; OTC: Tablets)
Effect of chenodiol
postural hypotension