Naftifine hydrochloride

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Naftifine hydrochloride
Naftifine hydrochloride (Naftin)
Naftifine hydrochloride
( NAF-tih-feen)
Pregnancy Category: B Naftin (Rx)

Classification: Antifungal agent

See Also: See also Anti-Infectives .

Action/Kinetics: Synthetic antifungal agent with a broad spectrum of activity. Thought to inhibit squalene 2,3-epoxidase, which is responsible for synthesis of sterols. The decreased levels of sterols (especially ergosterol) and the accumulation of squalene in cells result in fungicidal activity. Although used topically, approximately 6% of the drug is absorbed. Naftifine and its metabolites are excreted via the feces and urine. t 1/2: 2-3 days.

Uses: To treat tinea cruris, tinea pedis, and tinea corporis caused by Candida albicans, Epidermophyton floccosum, Microsporum canis, M. audouinii, M. gypseum, Trichophyton rubrum, T. mentagrophytes and T. tonsurans.

Contraindications: Ophthalmic use.

Special Concerns: Discontinue nursing while using naftifine and for several days after the last application. Safety and efficacy in children have not been determined.

Side Effects: Topical cream: Burning, stinging, dryness, itching, local irritation, erythema. Topical gel: Burning, stinging, itching, rash, tenderness, erythema.

How Supplied: Cream: 1%; Gel/jelly: 1%

?Topical Cream (1%), Topical Gel (1%)
Massage into affected area and surrounding skin once daily if using the cream and twice daily (morning and evening) if using the gel.

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