Questions | Reviews ***~

how does metronidazole change if the tablets are expired by a couple years

How does metronidazole change if the tablets are expired by a couple years?
by carol Taschek in northern new mexico, 08/24/2008

metronidazole dosage

I have been taking metronidazole 500 mg tablets, it has been very difficult for my body to accept this medication. I have all the side effects. I have to take it for 7 days but I would like to know if I can stop it now that I have taken it for 5 days....
by maria e. in los angeles,CA, 09/19/2006

STD and Metronidazole

I was dignose with an S.T.D im not sure what it was called but the doctor put me on 250mg of APO METRONIDAZOLE. He said that it would begin working right away. When he said that I asssumed that ment that the pain in my vigina would go away and the med...
by Michelle in Canada, 02/14/2006

Metronidazole and Ofloxacin reaction?

Hi, My name is Nicky and i'm taking METRONIDAZOLE 500 and i'm also taking OFLOXACIN 400. My question is Does these two medicine have a bad reaction when taken together? and I'm also had a side effect of confused, tired, short of breath, heart going ab...
by Nicky A in Miami, FLorida, 01/25/2006

side effects of metronidazole

What long side effects happen when you are on this Metronidazole for almost 10 days or more? I am expericeing severe joint pain ,memory loss and slur talking and cant' sleep and it makes me real tired too. I also have clogged bile ducts . Will this me...
by karen in port hadlock , wa, 12/11/2005

Metronidazole (Flagyl)
(meh-troh- NYE-dah-zohl)
Pregnancy Category: B Apo-Metronidazole Femazole Flagyl Flagyl 500 Injection Flagyl ER Flagyl I.V. Flagyl I.V. RTU Metric 21 Metro-Cream Topical MetroGel Topical MetroGel-Vaginal Metro I.V. MetroLotion Metryl Metryl-500 Metryl I.V. NidaGel Noritate Cream 1% Novo-Nidazol PMS-Metronidazole Protostat Satric Satric 500 Trikacide (Rx)

Classification: Systemic trichomonacide, amebicide

See Also: See also Anti-Infectives .

Action/Kinetics: Effective against anaerobic bacteria and protozoa. Specifically inhibits growth of trichomonae and amoebae by binding to DNA, resulting in loss of helical structure, strand breakage, inhibition of nucleic acid synthesis, and cell death. Well absorbed from GI tract and widely distributed in body tissues. Peak serum concentration: PO, 6-40 mcg/mL, depending on the dose, after 1-2 hr. t 1/2: PO, 6-12 hr average: 8 hr. Eliminated primarily in urine (20% unchanged), which may be red-brown in color following either PO or IV use. The mechanism for its effectiveness in reducing the inflammatory lesions of acne rosacea is not known.

Uses: Systemic: Amebiasis. Symptomatic and asymptomatic trichomoniasis; to treat asymptomatic partner. Amebic dysentery and amebic liver abscess. To reduce postoperative anaerobic infection following colorectal surgery, elective hysterectomy, and emergency appendectomy. Anaerobic bacterial infections of the abdomen, female genital system, skin or skin structures, bones and joints, lower respiratory tract, and CNS. Also, septicemia, endocarditis, hepatic encephalopathy. PO for Crohn's disease and pseudomembranous colitis. As part of the regimen to eradicate Helicobacter pylori infections. Investigational: Giardiasis, Gardnerella vaginalis.
Topical: Inflammatory papules, pustules, and erythema of rosacea. Investigational: Infected decubitus ulcers (use 1% solution prepared from oral tablets).
Vaginal: Bacterial vaginosis.

Contraindications: Blood dyscrasias, active organic disease of the CNS, trichomoniasis during the first trimester of pregnancy, lactation. Topical use if hypersensitive to parabens or other ingredients of the formulation. Consumption of alcohol during use.

Special Concerns: Safety and efficacy have not been established in children.

Side Effects: Systemic Use. G I: Nausea, dry mouth, metallic taste, vomiting, diarrhea, abdominal discomfort, constipation. CNS: Headache, dizziness, vertigo, incoordination, ataxia, confusion, irritability, depression, weakness, insomnia, syncope, seizures, peripheral neuropathy including paresthesias. Hematologic: Leukopenia, bone marrow aplasia. GU: Burning, dysuria, cystitis, polyuria, incontinence, dryness of vagina or vulva, dyspareunia, decreased libido. Allergic: Urticaria, pruritus, erythematous rash, flushing, nasal congestion, fever, joint pain. Miscellaneous: Furry tongue, glossitis, stomatitis (due to overgrowth of Candida) ECG abnormalities, thrombophlebitis.
Topical Use: Watery eyes if gel applied too closely to this area; transient redness; mild burning, dryness, and skin irritation.
Vaginal Use: Symptomatic candida vaginitis, N&V.

Overdose Management: Symptoms: Ataxia, N&V, peripheral neuropathy, seizures up to 5-7 days. Treatment: Supportive treatment.

Drug Interactions: Barbiturates / Possible therapeutic failure of metronidazole Cimetidine / Serum metronidazole levels R/T clearance Disulfiram / Concurrent use may cause confusion or acute psychosis Ethanol / Possible disulfiram-like reaction, including flushing, palpitations, tachycardia, and N&V Hydantoins / Hydantoins effect R/T clearance Lithium / Lithium toxicity Warfarin / Anticoagulant effect

How Supplied: Capsule: 375 mg; Cream: 0.75%, 1%; Gel/Jelly/Lotion: 0.75%; Injection: 500 mg/100 mL; Tablet: 250 mg, 500 mg; Tablet, Extended-Release: 750 mg

?Capsules, Tablets Amebiasis: Acute amebic dysentery or amebic liver abscess.
Adult: 500-750 mg t.i.d. for 5-10 days; pediatric: 35-50 mg/kg/day in three divided doses for 10 days.
Trichomoniasis, female.
250 mg t.i.d. for 7 days, 2 g given on 1 day in single or divided doses, or 375 mg b.i.d. for 7 days. Pediatric: 5 mg/kg t.i.d. for 7 days. An interval of 4-6 weeks should elapse between courses of therapy. NOTE: Do not treat pregnant women during the first trimester. Male: Individualize dosage; usual, 250 mg t.i.d. for 7 days.
Treat Helicobacter pylori infections.
One of the following regimens may be used: (1) Metronidazole, 500 mg b.i.d.; clarithromycin, 500 mg b.i.d.; and, either lansoprazole, 30 mg b.i.d. or omeprazole, 20 mg b.i.d. All drugs given for 2 weeks. (2) Metronidazole, 500 mg b.i.d. for 2 weeks, or amoxicillin, 1 g b.i.d. for 2 weeks, or tetracycline, 500 mg b.i.d. for 2 weeks; plus, clarithromycin, 500 mg b.i.d. for 2 weeks and ranitidine bismuth citrate, 400 mg b.i.d. for 4 weeks. (3) Tetracycline, 500 mg q.i.d.; metronidazole, 500 mg t.i.d.; bismuth subsalicylate, 525 mg q.i.d; and, either lansoprazole, 30 mg once daily or omeprazole, 20 mg once daily. All drugs given for 2 weeks. (4) Tetracycline, 500 mg q.i.d.; metronidazole, 250 mg q.i.d.; bismuth subsalicylate, 525 mg q.i.d.; and, a H2-receptor antagonist. Drugs are given for 2 weeks except for the H2-receptor antagonist which is given for 4 weeks.
250 mg t.i.d. for 7 days.
G. vaginalis.
500 mg b.i.d. for 7 days.
?Tablets, Extended-Release Bacterial vaginosis.
One 750-mg tablet per day for 7 days.
?IV Anaerobic bacterial infections.
Adults, initially: 15 mg/kg infused over 1 hr; then, after 6 hr, 7.5 mg/kg q 6 hr for 7-10 days (daily dose should not exceed 4 g). Treatment may be necessary for 2-3 weeks, although PO therapy should be initiated as soon as possible.
Prophylaxis of anaerobic infection during surgery.
Adults: 15 mg/kg given over a 30- to 60-min period, with completion 1 hr prior to surgery and 7.5 mg/kg infused over 30-60 min 6 and 12 hr after the initial dose.
?Topical (0.75%, 1%) Rosacea.
After washing, apply a thin film and rub in well either once daily or b.i.d. in the morning and evening for 4-9 weeks.
?Vaginal (0.75%) Bacterial vaginosis.
One applicatorful (5 g) in the morning and evening for 5 days. Metro-Gel Vaginal allows for once-daily dosing at bedtime.

Metronidazole Ratings

Overall Rating:



(based on 6 reviews)



Ease of Use:


Overall Satisfaction:





Effectiveness: **

Ease of Use: **

Overall Satisfaction: *


Brenda, Ohio - 03/05/2012

I took this 2 months ago for the same problem, bacterial infection, and here I'm taking this terrible tasting medication again, I don't know why I keep getting this infection back, I'm not sexual active n can't be from that, I have a question though, does this medication cause tiredness also short of breath? This didn't start until after I started taking this, I'm very worried about this, Thank You


Effectiveness: ****

Ease of Use: ****

Overall Satisfaction: ***


Eve, FL - 09/30/2011

My mother and I were both prescribed Metronidazole 500 mg tablets due to BV. I was prescribed to take it for 7 days and she was for 5 days. We both started the same day, my period had also started that day, which was good, because the doctor said we might have some discharge while we take the tablets, so i didnt have to deal with any of that. I had no symptoms or problems through out the 7 days of taking them, my mom was a bit nauseous and had a slight diarrhea. My mom was done with her treatmenr first and about 2 days later she started gettin itchy, burning sensation as well as white clumpy discharge. She said that that area was also very raw. But there was no smell. About 5 days after I was done with the treatment I started to get the same symptoms as her, very raw feeling, a lot of white clumpy discharge, itchiness, very uncomfortable and painful feeling. We really didnt know what to do, so to stop the rawness feeling we ended up putting organic oil around and in it. A lot of washing with warm water also helped. It got better about 7-8 days later. As far as the tablets I think they did what they were supposed to, because we both have no more discharge, any type of smell or itchiness but I just think it was too strong of a dosage for both of us. It killed the bad and the good bacteria... Definitely talk to your doctor about the symptoms and what it can possibly do. And if you dont get answers do your research. Both of our doc's said there were going to be no problems after we were done taking the medication, that was boviously not the correct information.


Effectiveness: ****

Ease of Use: *****

Overall Satisfaction: *****


Sepali, Essex, England - 06/17/2009

I started to take Metronidazole on October 22. I have had some occasional stomach cramps and it does leave a bit of a bad taste in my mouth, but I have not had any dizziness or other side effects that some others have. I did have mixed drink one time, but it did not cause any issues. Within the first 24 hours of taking Metronidazole all of my symptoms were gone. I generally take it with a glass of milk and I have also been eating yogurt on a regular basis.


Effectiveness: ****

Ease of Use: ***

Overall Satisfaction: ***


fastball55, McDonough, GA - 01/14/2008

I experienced a lot of the common symptoms of Metronidazole while on the medication. Thankfully, I completed my prescription today. While taking the medication, I felt exhausted, irritable, and weak. I experienced headaches, dizziness, and a loss of appetite. Finally, I even had a weird and disgusting furry tongue and a sore throat. My recommendation is that everyone who is on this drug or thinking about taking it do some research ahead of time. Learn about the drug and it's side effects. For me, the drug is working, but I've read reviews where people have more extreme and scarier side effects, such as tumors or cancer. I think everyone should be informed if they are considering this drug. Finally, one piece of advice: you should not drink grapefruit juice while on the medication, because grapefruit could hinder your liver from processing the drug. I hope this helps everyone.