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Action/Kinetics:
Active against many gram-positive and gram-negative organisms and in the presence of serum and pus. When applied topically, it diffuses through devascularized areas, is absorbed, and is rapidly metabolized.
Uses:
Topical application to prevent infections in second- and third-degree burns. To control bacterial infections when used under moist dressing over meshed autografts on excised burn wounds.
Contraindications:
Use for established infections or in infants less than 1 month of age.
Special Concerns:
Use with caution during lactation and in those with acute renal failure.
Side Effects:
Allergic: Rash, itching, swelling, hives, blisters, facial edema, erythema, eosinophilia.
Dermatologic: Pain or burning (common) on application; excoriation of new skin, bleeding (rare).
Respiratory: Hyperventilation or tachypnea, decrease in arterial pCO
2.
Metabolic: Acidosis, increase in serum chloride.
Miscellaneous:
Fatal hemolytic anemia with DIC diarrhea.
How Supplied:
Cream: 85 mg/g;
Powder for Topical Solution: 5%;
Topical Powder: 50 g/packet
Dosage
?Cream
1/16-in.-thick film applied over entire surface of burn with gloves once or twice daily until healing is progressing satisfactorily or until site is ready for grafting.
