Loxapine hydrochloride

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Loxapine hydrochloride
Loxapine hydrochloride (Loxitane)
( LOX-ah-peen)
Pregnancy Category: C Loxapac Loxitane C Loxitane IM (Rx)
Loxapine succinate
Loxapine succinate (Loxitane)
( LOX-ah-peen)
Pregnancy Category: C Loxapac Loxitane (Rx)

Classification: Antipsychotic, tricyclic

See Also: See also Antipsychotic Agents, Phenothiazines .

Action/Kinetics: Thought to act by blocking dopamine at postsynaptic brain receptors. Causes significant extrapyramidal symptoms, moderate sedative effects, and a low incidence of anticholinergic effects, as well as orthostatic hypotension. Onset: 20-30 min. Peak effects: 1.5-3 hr. Duration: about 12 hr. t 1/2: 3-4 hr. Partially metabolized in the liver; excreted in urine, and unchanged in feces.

Uses: Psychotic disorders. Investigational: Anxiety neurosis with depression.

Additional Contraindications History of convulsive disorders.

Special Concerns: Use with caution in clients with CV disease. Use during lactation only if benefits outweigh risks. Dosage has not been established in children less than 16 years of age. Geriatric clients may be more prone to developing orthostatic hypotension, anticholinergic, sedative, and extrapyramidal side effects.

Additional Side Effects: Tachycardia, hypertension, hypotension, lightheadedness, and syncope.

How Supplied: Loxapine hydrochloride: Concentrate: 25 mg/mL; Injection: 50 mg/mL Loxapine succinate: Capsule: 5 mg, 10 mg, 25 mg, 50 mg

?Capsules, Oral Solution Psychoses.
Adults, initial: 10 mg (of the base) b.i.d. For severe cases, up to 50 mg/day may be required. Increase dosage rapidly over 7-10 days until symptoms are controlled. Range: 60-100 mg up to 250 mg/day. Maintenance: If possible reduce dosage to 20-60 mg/day.
?IM Psychoses.
Adults: 12.5-50 mg (of the base) q 4-6 hr; once adequate control has been established, switch to PO medication after control achieved (usually within 5 days).

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Loxapine hydrochloride

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Ease of Use: *

Overall Satisfaction: ***


Alex, Alex - 01/12/2014

This seems like a very powerful early diaongstic tool, and also very useful as a way to pre-test personalized medication regimes without the usual trial and error process - at least by drug type. Biomarker tests for schitzophrenia seem to only have validity in the early symptomatic (or subclinical) stage, while something based on genes could theoretically be done on newborns or two year olds that have a family history of the disease.It would also be interesting to see if the same technique used to distinguish cells from non-schitzophrenic individuals from cells from schitzophrenic individuals could be used to diagnose subtypes of schitzophrenia or to answer questions like whether schitzophrenia and bipolar are overlapping conditions that just happen to manifest differently in different people or are diaongstically distinct at a genetic level.