Lomefloxacin hydrochloride

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Lomefloxacin hydrochloride tablet

                      Lomefloxacin hydrochloride  tablet  is markted as racemic or single enanatiomer ?      
by Abdalla in Malaysia, 10/08/2006

Lomefloxacin hydrochloride
Lomefloxacin hydrochloride (Maxaquin)
Lomefloxacin Hydrochloride
( loh-meh- FLOX-ah-sin)
Pregnancy Category: C Maxaquin (Rx)

Classification: Antibacterial, fluoroquinolone derivative

See Also: See also Fluoroquinolones .

Action/Kinetics: Mean peak plasma levels: 4.2 mcg/mL after a 400-mg dose. The rate and extent of absorption are decreased if taken with food. t 1/2: 8 hr. Metabolized in the liver with 65% excreted unchanged through the urine and 10% excreted unchanged in the feces.

Uses: Acute bacterial exacerbation of chronic bronchitis caused by Haemophilus influenzae or Morazella catarrhalis. Uncomplicated UTIs due to Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis or Staphylococcus saprophyticus. Complicated UTIs due to E. coli, K. pneumoniae, P. mirabilis, Pseudomonas aeruginosa, Citrobacter diversus or Enterobacter cloacae. Preoperatively to decrease the incidence of UTIs 3-5 days after surgery in clients undergoing transurethral procedures. Uncomplicated gonococcal infections. Prevent infection in preoperative transrectal prostate biopsy.

Contraindications: Use in minor urologic procedures for which prophylaxis is not indicated (e.g., simply cystoscopy, retrograde pyelography). Use for the empiric treatment of acute bacterial exacerbation of chronic bronchitis due to Streptococcus pneumoniae. Lactation.

Special Concerns: Plasma clearance is reduced in the elderly. Safety and efficacy have not been determined in children less than 18 years of age. Serious hypersensitivity reactions that are occasionally fatal have occurred, even with the first dose. No dosage adjustment is needed for elderly clients with normal renal function. Not efficiently removed from the body by hemodialysis or peritoneal dialysis.

Additional Side Effects: CNS: Confusion, tremor, vertigo, nervousness, anxiety, hyperkinesia, anorexia, agitation, increased appetite, depersonalization, paranoia, coma. GI: GI inflammation or bleeding, dysphagia, tongue discoloration, bad taste in mouth. GU: Dysuria, hematuria, micturition disorder, anuria, strangury, leukorrhea, intermenstrual bleeding perineal pain, vaginal moniliasis, orchitis, epididymitis, proteinuria, albuminuria. Hypersensitivity Reactions: Urticaria, itching, pharyngeal or facial edema, CV collapse tingling, loss of consciousness, dyspnea. CV: Hypotension, tachycardia, bradycardia, extrasystoles, cyanosis, arrhythmia, cardiac failure angina pectoris, MI, pulmonary embolism, cardiomyopathy phlebitis, cerebrovascular disorder. Respiratory: Dyspnea, respiratory infection, epistaxis, bronchospasm cough, increased sputum, respiratory disorder, stridor. Hematologic: Eosinophilia, leukopenia, increase or decrease in platelets, increase in ESR, lymphocytopenia, decreased hemoglobin, anemia, bleeding, increased PT, increase in monocytes. Dermatologic: Urticaria, eczema, skin exfoliation, skin disorder. Ophthalmologic: Conjunctivitis, eye pain. Otic: Earache, tinnitus. Musculoskeletal: Back or chest pain, asthenia, leg cramps, arthralgia, myalgia. Miscellaneous: Increase or decrease in blood glucose, flushing, increased sweating, facial edema, influenza-like symptoms, decreased heat tolerance, purpura, lymphadenopathy, increased fibrinolysis, thirst, gout, hypoglycemia, phototoxicity.

Laboratory Test Alterations: ALT, AST, alkaline phosphatase, bilirubin, BUN, gamma-glutamyltransferase. or Potassium. Abnormalities of urine specific gravity or serum electrolytes.

How Supplied: Tablet: 400 mg

?Tablets Acute bacterial exacerbation of chronic bronchitis. Cystitis.
Adults: 400 mg once daily for 10 days.
Complicated UTIs.
Adults: 400 mg once daily for 14 days.
Uncomplicated UTIs.
400 mg once daily for 3 days.
Prophylaxis of infection before surgery for transurethral procedures.
Single 400-mg dose 2-6 hr before surgery.
Uncomplicated gonococcal infections.
400 mg as a single dose (as an alternative to ciprofloxacin or ofloxacin).

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Lomefloxacin hydrochloride

Effectiveness: **

Ease of Use: ***

Overall Satisfaction: ****


Hassin, Hassin - 01/14/2014

"No placebo cnoortl."Might this be due to ethical concerns? Withholding a proven treatment for a disease seems wrong. Comparing to treatment as usual might not be ideal from a study design perspective, but for (say) someone with depression to go 6 weeks with a placebo seems cruel and dangerous.Loved the journal for both articles, thanks for sharing!