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Any Interaction between Nifedipine or Lisinopril

I am taking 20 mg of Lisinopril twice a day and Nifedipine (XI) 30 mg once a day for high blood pressure. Do these two medications compliment each other and are they safe to take together? Thank You!!! Jan Burns
by Jan Burns in Phoenix, AZ, 10/06/2014


I recently started Lisinopril at 10 mg. The dose has been increased to 20 mg. for better BP control. I find this dose makes me tired-fatigued, but it has helped my blood pressure come down. Can a 20 mg. dose be taken closer to bedtime, such as around ...
by Susan in Cumberland, RI- USA, 08/02/2006

10/12.5 Lisinopril/HCTZ

Am currently taking one tab of 10/12.5 Lisinopril/HCTZ daily and my blood pressure is running 140/high 80's. Would there be any harm is increasing the doseage to two tabs/day.   Thanks in advance, John
by John Denham in Cleveland, Ohio, 05/03/2008

Lisinopril dosage

Do you see any harm in taking Lisonopril every other day? I currently take 2 1/2 mg and my pressure stays low for two days after.
by Joanne in NY, 05/07/2007

side effects of lisinopril

  how many people die on lisinopril per year?
by Lillian in South Bend, IN, 08/20/2007

View All 11 Questions

Lisinopril (Prinivil, Zestril)
(lie- SIN-oh-prill)
Pregnancy Category: C Apo-Lisinopril Prinivil Zestril (Rx)

Classification: Antihypertensive, ACE inhibitor

See Also: See also Angiotensin-Converting Enzyme Inhibitors .

Action/Kinetics: Both supine and standing BPs are reduced, although the drug is less effective in blacks than in Caucasians. Although food does not alter the bioavailability of lisinopril, only 25% of a PO dose is absorbed. Onset: 1 hr. Peak serum levels: 7 hr. Duration: 24 hr. t 1/2: 12 hr. 100% of the drug is excreted unchanged in the urine.

Uses: Alone or in combination with a diuretic (usually a thiazide) to treat hypertension. In combination with digitalis and a diuretic for treating CHF not responding to other therapy. Use within 24 hr of acute MI to improve survival in hemodynamically stable clients (clients should receive the standard treatment, including thrombolytics, aspirin, and beta blockers).

Special Concerns: Use with caution during lactation. Safety and efficacy have not been established in children. Geriatric clients may manifest higher blood levels. Reduce the dosage in clients with impaired renal function.

Side Effects: CV: Hypotension, orthostatic hypotension, angina, tachycardia, palpitations, rhythm disturbances, stroke chest pain, orthostatic effects, peripheral edema, MI, CVA worsening of heart failure, chest sound abnormalities, PVCs, TIAs, decreased blood pressure, atrial fibrillation. CNS: Dizziness, headache, fatigue, vertigo, insomnia, depression, sleepiness, paresthesias, malaise, nervousness, confusion, ataxia, impaired memory, tremor, irritability, hypersomnia, peripheral neuropathy, spasm. GI: Diarrhea, N&V, dyspepsia, anorexia, constipation, dysgeusia, dry mouth, abdominal pain, flatulence, dry mouth, gastritis, heartburn, GI cramps, weight loss/gain, taste alterations, increased salivation. Respiratory: Cough, dyspnea, bronchitis, upper respiratory symptoms, nasal congestion, sinusitis, pharyngeal pain, bronchospasm, asthma pulmonary edema, pulmonary embolism, pulmonary infarction paroxysmal nocturnal dyspnea, chest discomfort, common cold, nasal congestion, pulmonary infiltrates, pleural effusion, wheezing, painful respiration, epistaxis, laryngitis, pharyngitis, rhinitis, rhinorrhea, orthopnea. Musculoskeletal: Asthenia, muscle cramps, neck/hip/leg/knee/arm/joint/shoulder/back/pelvic/flank pain, myalgia, arthralgia, arthritis, lumbago. Hepatic: Hepatitis, hepatocellular/cholestatic jaundice, pancreatitis, hepatomegaly. Dermatologic: Rash, pruritus, flushing, increased sweating, urticaria, alopecia, erythema multiforme, photophobia. GU: Impotence, oliguria, progressive azotemia, acute renal failure, UTI, anuria, uremia, renal dysfunction, pyelonephritis, dysuria. Ophthalmic: Blurred vision, visual loss, diplopia. Miscellaneous: Angioedema (may be fatal if laryngeal edema occurs) hyperkalemia, neutropenia, anemia, bone marrow depression decreased libido, fever, syncope, vasculitis of the legs, gout, eosinophilia, fluid overload, dehydration, diabetes mellitus, chills, virus infection, edema, anaphylactoid reaction malignant lung neoplasms, hemoptysis, breast pain.

Laboratory Test Alterations: Serum potassium, BUN, serum creatinine. H&H.

Overdose Management: Symptoms: Hypotension. Treatment: Supportive. To correct hypotension, IV normal saline is treatment of choice. Lisinopril may be removed by hemodialysis.

Drug Interactions: Diuretics / Excess BP Indomethacin / Possible lisinopril effect Potassium-sparing diuretics / Significant serum potassium

How Supplied: Tablet: 2.5 mg, 5 mg, 10 mg, 20 mg, 40 mg

?Tablets Essential hypertension, used alone.
Initial: 10 mg once daily. Adjust dosage depending on response (range: 20-40 mg/day given as a single dose). Doses greater than 80 mg/day do not give a greater effect.
Essential hypertension in combination with a diuretic.
Initial: 5 mg. The BP-lowering effects of the combination are additive. Reduce dosage in renal impairment as follows: C CR, 10-30 mL/min; give an initial dose of 5 mg /day for hypertension. C CR, less than 10 mL/min; give an initial dose of 2.5 mg/day and adjust dose depending on BP response.
Initial: 5 mg once daily (2.5 mg/day in clients with hyponatremia) in combination with diuretics and digitalis. Dosage range: 5-20 mg/day as a single dose.
Acute MI.
First dose: 5 mg; then 5 mg after 24 hr, 10 mg after 48 hr, and then 10 mg daily. Continue dosing for 6 weeks. In clients with a systolic pressure less than 120 mm Hg when treatment is started or within 3 days after the infarct should be given 2.5 mg. If hypotension occurs (systolic BP less than 100 mm Hg), the dose may be temporarily reduced to 2.5 mg. If prolonged hypotension occurs, withdraw the drug.

Lisinopril Ratings

Overall Rating:



(based on 2 reviews)



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Overall Satisfaction:





Effectiveness: ***

Ease of Use: ***

Overall Satisfaction: ***


DALE GUYTON, akron, oh - 01/13/2008

The doseages are difficult to determine at times. This causes the b/p to result in high or low readings.


Effectiveness: *****

Ease of Use: *****

Overall Satisfaction: *****


Dera , United Kingdom - 07/22/2009

This is my first time using this product. I am still getting used to the side effects and how it helps my blood pressure come down. I am looking forward to getting my blood pressure down and living a long life even if I have to continue this medication for a long time.