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Letrozole (Femara)
( LET-roh-zohl)
Pregnancy Category: D Femara (Rx)

Classification: Antineoplastic, hormone

See Also: See also Antineoplastic Agents.

Action/Kinetics: A nonsteroidal competitive inhibitor of aromatase, resulting in inhibition of conversion of androgens to estrogens. It acts by competitively binding to heme of cytochrome P450 subunit of aromatase, leading to decreased biosynthesis of estrogen in all tissues. Does not cause increase in serum FSH and does not affect synthesis of adrenocorticosteroids, aldosterone, or thyroid hormones. t 1/2, elimination: About 2 days. Steady state plasma levels after daily doses of 2.5 mg reached in 2 to 6 weeks. Inactive metabolites are excreted in urine.

Uses: Advanced breast cancer in postmenopausal women with disease progression following antiestrogen therapy.

Special Concerns: Use with caution during lactation and in those with severely impaired hepatic function. Safety and efficacy have not been determined in children.

Side Effects: CNS: Headache, somnolence, dizziness, vertigo, depression, anxiety. GI: N&V, constipation, diarrhea, abdominal pain, anorexia, dyspepsia. Body as a whole: Fatigue, viral infections, peripheral edema, asthenia, decreased weight. Dermatologic: Hot flashes, rash, pruritus, alopecia, increased sweating. Respiratory: Dyspnea, coughing, pleural effusion. Miscellaneous: Chest pain, hypertension, arthralgia, fracture.

Laboratory Test Alterations: AST, ALT, GGT. Lymphocyte counts. Hypercholesterolemia, hypercalcemia.

How Supplied: Tablet: 2.5 mg

?Tablets Advanced breast cancer.
Adults and elderly: 2.5 mg once/day. Continue until tumor progression is evident. Dosage adjustment is not needed in renal impairment if C CR is greater than or equal to 10 mL/min.

Letrozole Ratings

Overall Rating:



(based on 2 reviews)



Ease of Use:


Overall Satisfaction:





Effectiveness: *

Ease of Use: ***

Overall Satisfaction: *****


Edi, Edi - 01/15/2014

Oh shit, Scorchy! It is a disgrace that you are still in this much pain. I think the raidotian will help, but it takes time you may get a pain spike first. So you really, really, really need pain medication that works and enough that you can adjust it as pain goes up and down. With my combo of dilaudid (regular and long-acting), lyrica and naprosyn, I'm attacking the pain from all sides. Sure, I was loopy when I first went on the dilaudid, but it only lasted a week or two. You should have seen me when i was on the pain pump! Now, I can drive on the stuff. I can't imagine how I would function without it. I pay the price if I forget a dose.You are always in my thoughts and in my prayers. No one should suffer like this. I hope making a stink will get those doctors on the ball. Enough is enough!