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Ketoconazole for prostate cancer

My husband was advised to take 1200 mg of ketoconzole a day for treatment of advanced prostate cancer. It was suggested that he take the pills(200 mg each) 2 in the morning, 2 in the afternoon and 2 at night...with orange juice. What is the significan...
by Barbara Germano in Destin Florida USA, 07/27/2006


  I would like to ask you about ketoconazole. Can available commercial product of ketoconazole easily be absorbed? How much bioavailabily of ketoconazole? Thank you very much. Chanadda, Thailand 
by Chanadda in Thailand, 09/17/2006

Can KETOCONAZOLE cause a false positive on Drug test

I gave my son a drug test to checking for THC and cocaine. The test was administered approximately 3 hours after taking a Dr prescribed dose of 2 200mg tablets/week for a fungil rash. Upon taking the test he showed negative for THC but positive for th...
by CJ Sebastian in Baytown, TX, 06/25/2006

Ketoconazole (Nizoral)
(kee-toe- KON-ah-zohl)
Pregnancy Category: C Nizoral (Rx) Nizoral AD (OTC)

Classification: Broad-spectrum antifungal

See Also: See also Anti-Infectives .

Action/Kinetics: Inhibits synthesis of sterols (e.g., ergosterol), damaging the cell membrane and resulting in loss of essential intracellular material. Also inhibits biosynthesis of triglycerides and phospholipids and inhibits oxidative and peroxidative enzyme activity. When used to treat Candida albicans it inhibits transformation of blastospores into the invasive mycelial form. Inhibits growth of Pityrosporum ovale when used to treat dandruff. Use in Cushing's syndrome is due to its ability to inhibit adrenal steroidogenesis. Peak plasma levels: 3.5 mcg/mL after 1-2 hr after a 200-mg dose. t 1/2 [biphasic]: first, 2 hr; second, 8 hr. Requires acidity for dissolution. Metabolized in liver to inactive metabolites and most excreted through feces.

Uses: PO: Candidiasis, chronic mucocutaneous candidiasis, candiduria, histoplasmosis, chromomycosis, oral thrush, blastomycosis, coccidioidomycosis, paracoccidioidomycosis. Recalcitrant cutaneous dermatophyte infections not responding to other therapy. Cream: Tinea pedis. Tinea corporis and tinea cruris due to Trichophyton rubrum, T. mentagrophytes and Epidermophyton floccosum. Tinea versicolor caused by Microsporum furfur; cutaneous candidiasis caused by Candida species; seborrheic dermatitis. Shampoo: To reduce scaling due to dandruff and tinea versicolor. Investigational: Onychomycosis due to Candida and Trichophyton. High doses to treat CNS fungal infections. Advanced prostate cancer, Cushing's syndrome.

Contraindications: Hypersensitivity, fungal meningitis. Topical product not for ophthalmic use. Use during lactation.

Special Concerns: Use tablets with caution in children less than 2 years of age. The safety and effectiveness of the shampoo and cream have not been determined in children. Use with caution during lactation.

Side Effects: GI: N&V, abdominal pain, diarrhea. CNS: Headache, dizziness, somnolence, fever, chills, suicidal tendencies, depression (rare). Hematologic: Thrombocytopenia, leukopenia, hemolytic anemia. Miscellaneous: Hepatotoxicity, photophobia, pruritus, gynecomastia, impotence, bulging fontanelles, urticaria, decreased serum testosterone levels, anaphylaxis (rare). Topical cream: Stinging, irritation, pruritus. Shampoo: Increased hair loss, irritation, abnormal hair texture, itching, oiliness or dryness of the scalp and hair, scalp pustules.

Laboratory Test Alterations: Transient serum liver enzymes. Serum testosterone.

Drug Interactions: Antacids / Absorption of ketoconazole R/T pH Anticoagulants / Anticoagulant effect Anticholinergics / Absorption of ketoconazole R/T pH Cisapride / Risk of serious cardiac arrhythmias Corticosteroids / Risk of drug toxicity R/T bioavailability Cyclosporine / Cyclosporine levels (ketaconazole may be used therapeutically to decrease cyclosporine dose) Donepezil / Plasma levels of donepezil R/T liver metabolism Histamine H 2 antagonists / Ketoconazole absorption R/T pH Isoniazid / Bioavailability of ketoconazole Nisoldipine / Nisoldipine plasma levels R/T liver metabolism Rifampin / Serum levels of both drugs Theophyllines / Serum theophylline levels Zolpidem / Half-life of zolpidem R/T liver metabolism

How Supplied: Cream: 2%; Shampoo: 1%, 2%; Tablet: 200 mg

?Tablets Fungal infections.
Adults: 200 mg once daily; in serious infections or if response is not sufficient, increase to 400 mg once daily. Pediatric, over 2 years: 3.3-6.6 mg/kg once daily. Dosage has not been established for children less than 2 years of age.
CNS fungal infections.
Adults: 800-1,200 mg/day.
Advanced prostate cancer.
400 mg q 8 hr.
Cushing's syndrome.
800-1,200 mg/day.
?Topical Cream (2%) Tinea corporis, tinea cruris, tinea versicolor, tinea pedis, cutaneous candidiasis.
Cover the affected and immediate surrounding areas once daily (twice daily for more resistant cases). Duration of treatment is usually 2 weeks.
Seborrheic dermatitis.
Apply to affected area b.i.d. for 4 weeks or until symptoms clear.
?Shampoo (1%, 2%)
Use twice a week for 4 weeks with at least 3 days between each shampooing. Then, use as required to maintain control.

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