Isotretinoin


Questions | Reviews **~

Isotretinoin and alcohol consumption


Teenager, 18 year old male, going to Prom and is curently on Claravis. I'm concerend about physical reaction if alcohol is consumed. Please let me know.
by Angie R in Northbrook, IL, 05/18/2006

Isotretinoin killed my clitoris and Lord only knows what it did to my brain


HI, I am writing because i have been lately very concerned about my health, i have taken the first course of isotretinoin treatment for 20 weeks: 20mg / day the first 4 weeks and 10mg/day for 16 weeks, and from which i emerged with no serious damage, ...
by sanae in morocco, rabat, 09/20/2006

Isotretinoin
Isotretinoin (Accutane)
Isotretinoin
(eye-so- TRET-ih-noyn)
Pregnancy Category: X Accutane Accutane Roche Isotrex (Rx)

Classification: Vitamin A metabolite (antiacne, keratinization stabilizer)

Action/Kinetics: Reduces sebaceous gland size, decreases sebum secretion, and inhibits abnormal keratinization. Approximately 25% of the PO dosage form is bioavailable. Peak plasma levels: 3 hr. Steady-state blood levels following 80 mg/day: 160 ng/mL. Nearly 100% bound to plasma protein. t 1/2: 10-20 hr. Metabolized in the liver to 4-oxo-isotretinoin, which is also active. Approximately equal amounts are excreted through the urine and in the feces.

Uses: Severe recalcitrant cystic acne unresponsive to other therapy. Investigational: Cutaneous disorders of keratinization, cutaneous T-cell lymphoma (mycosis fungoides), leukoplakia, prevention of secondary primary tumors in those treated for squamous-cell carcinoma of the head and neck.

Contraindications: Due to the possibility of fetal abnormalities or spontaneous abortion, women who are pregnant or intend to become pregnant should not use the drug. Certain conditions for use should be met in women with childbearing potential (see package insert). Use during lactation and in children.

Special Concerns: Intolerance to contact lenses may develop.

Side Effects: Skin: Cheilitis, skin fragility, pruritus, dry skin, desquamation of facial skin, drying of mucous membranes, brittle nails, photosensitivity, rash, hypo- or hyperpigmentation, urticaria, erythema nodosum, hirsutism, excess granulation of tissues as a result of healing, petechiae, peeling of palms and soles, skin infections, paronychia, thinning of hair, nail dystrophy, pyogenic granuloma, bruising. CNS: Headache, fatigue, pseudotumor cerebri (i.e., headaches, papilledema, disturbances in vision), depression. Ocular: Conjunctivitis, optic neuritis, corneal opacities, dry eyes, decrease in acuity of night vision, photophobia, eyelid inflammation, cataracts, visual disturbances. GI: Dry mouth, N&V, abdominal pain, nonspecific GI symptoms, inflammatory bowel disease (including regional enteritis), anorexia, weight loss, inflammation and bleeding of gums. Neuromuscular: Arthralgia, muscle pain, bone and joint pain and stiffness, skeletal hyperostosis. CV: Flushing, palpitation, tachycardia. GU: White cells in urine, proteinuria, nonspecific urogenital findings, microscopic or gross hematuria, abnormal menses. Other: Epistaxis, dry nose and mouth, respiratory infections, disseminated herpes simplex, edema, transient chest pain, development of diabetes, hepatitis, hepatotoxicity, vasculitis, anemia, lymphadenopathy, flushing, palpitations.

Laboratory Test Alterations: Plasma triglycerides, sedimentation rate, platelet counts, alkaline phosphatase, AST, ALT, GGTP, LDH, fasting blood glucose, uric acid in blood, cholesterol, CPK levels in clients who exercise vigorously. HDL, RBC parameters, WBC counts.

Overdose Management: Symptoms: Abdominal pain, ataxia, cheilosis, dizziness, facial flushing, headache, vomiting. Symptoms are transient. Treatment: Symptoms are quickly resolved with drug cessation or decrease in dose.

Drug Interactions: Alcohol / Potentiation of serum triglycerides Benzoyl peroxide / Drying effects of isotretinoin Carbamazepine / Plasma carbamazepine levels Minocycline / Risk of developing pseudotumor cerebri or papilledema Tetracycline / Risk of developing pseudotumor cerebri or papilledema Tretinoin / Drying effects of isotretinoin Vitamin A / Risk of toxicity

How Supplied: Capsule: 10 mg, 20 mg, 40 mg

Dosage
?Capsules Recalcitrant cystic acne.
Adults, individualized, initial: 0.5-1 mg/kg/day (range: 0.5-2 mg/kg/day) divided in two doses for 15-20 weeks. Adjust dose based on toxicity and clinical response; if cyst count decreases by 70% or more, drug may be discontinued. If necessary, a second course of therapy may be instituted after a rest period of 2 months. Doses of 0.05-0.5 mg/kg/day are effective but result in higher frequency of relapses.
Keratinization disorders.
Doses up to 4 mg/kg/day have been used.
Prevent second tumors in squamous-cell carcinoma of the head and neck.
50-100 mg/m 2.

Isotretinoin Ratings

Overall Rating:

2.5**~

 

(based on 2 reviews)

Effectiveness:

**

Ease of Use:

****

Overall Satisfaction:

**

Reviewit

Reviews

Isotretinoin
3.5

Effectiveness: ***

Ease of Use: *****

Overall Satisfaction: ***

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Jackie, Jackie - 01/15/2014

Please check if you have any allergies or sseiitnvity with some ingredients; such as glycerin, lemons, orange, garlic, papaya, eggs, etc. The following acne treatment and cures are good for all body acne including scalp acne. After you have successfully treated your acne, you will need to treat your acne scars, if any.Acne usually begins with blackheads. Blackheads are formed when oil and dead cells get trapped in a pore. They then turn black when exposed to air. When blackheads become inflamed, they become red (pimples). They multiply when touched with dirty hands. So to get rid of acne, you should also try blackhead remedies.Acne, Pimples : Causes, PreventionAcne preventionHow to get rid of Acne ScarsAdult acneGlowing Smooth Skin TipsMore >>Zinc, Vitamin A, B E, echinacea, thyme and tea tree oil can cure acne. Vitamin B complex can improve your acne dramatically. Take vitamin B tablet containing all the B viramins, you should see results in a few weeks.Carbohydrate foods with low glycemic index or a low GI diet can improve acne by 50 percent.Grind nutmeg (jaiphal) with unboiled milk and apply on acne for 1-2 hours. This works as a magic. Pimples should disappear without leaving a mark.Make a paste by mixing honey and cinnamon powder. Apply this paste on the pimples before sleeping and wash it next morning with warm water. Repeat for two weeks, pimples will disappear forever.Rub fresh garlic on and around pimples. Pimples will disappear without a mark with regular applications.Mix 1 tablespoon groundnut oil with 1 tablespoon fresh lime juice to prevent formation of blackheads and acne.Ground drumstick pods and leaves and mix mixed with fresh lime juice, and apply on pimples. This is also good for blackheads and dark spots.Apply juice of raw papaya (including the skin and seed) on swelling pimples or acne.Apply fresh lime juice mixed to a glass of boiled milk as a face wash for pimples, blackheads, and cracked skin.Mix lime juice and rose water in equal portions. Apply on affected area. Wash it off after 20-30 minutes with lukewarm water.Apply ripe tomato or cucumber pulp on acne pimples and keep upto 1 hour, then wash.Apply a mixture of 1 teaspoon lemon juice and 1 teaspoon cinnamon powder. Note that this remedy is not for sensitive skin.Make a paste of roasted powdered pomgranate skin with fresh lime juice and apply over boils,acne, pimple, blackheads and whiteheads.Apply grated potatoes as poultice to treat skin blemishes, wrinkles, boils, pimples, blackheads, whiteheads , etc.Make a paste of sandalwood with rose water. Apply on affected area. Wash it off after 20-30 minutes with lukewarm water.Make a paste of ground radish seeds with water and apply on face to remove blackheads.Apply a paste of ground seasame seeds with water as poultice for inflammation of the skin due to allergies, skin rashes, and pimples acne.Apply a paste of fresh fenugreek methi leaves over the face every night and wash with warm water in the morning for preventing pimples, blackheads, whiteheads, dryness, and wrinkles.Make a paste of ground orange peel with water and apply on the affected area. Wash it off after 20-30 minutes with lukewarm water.Make a paste of salt in vinegar. Rub it on the pimples. Wash it off after 20-30 minutes with lukewarm water.Make a paste of turmeric powder in mint juice. Apply on affected area. Wash it off after 20-30 minutes with lukewarm water.Apply fresh mint juice over face every night for pimples or acne prevention. Fresh mint juice is good for the treatment of pimples, insect stings, eczema, scabies, other skin infections.juhnhyyyMake a paste of neem leaves with turmeric powder. Apply on affected area. Wash it off after 20-30 minutes with lukewarm water. This is a good cure of acne.Drinking of wheatgrass juice may remove acne.Acne on ScalpScalp acne is treated in the same manner as the acne on face. Try any of the remedies given above.Dip a cotton ball in a skin cleanser containing salicylic acid and apply on the acne area.Do not use any acne cream/oil containing benzoil peroxide or other peroxide ingredients on the scalp because it may change the color of your hair.Mix 4 parts tea tree oil to 1 part lavender oil in olive oil or any other oil and apply to the scalp as a shampoo. This works as a wonder if your scalp problem is due to any infection.Boil a cup of neem leaves in water. Wash your head with this water when it is warm. I HOpe i helpedif , then please dnt forget to vote me