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Indomethacin duration of usage for gout?

I am taking indomethacin ( 50 mg ) for gout but am wondering how long I need to keep taking the capsules. I get quick relief from the pain but even after a few days there is still a nagging ache. Should I keep taking the medicine until I am totally pa...
by Dave Christie in Calgary, Alberta Canada, 12/28/2005

Indomethacin (Indocin)
(in-doh- METH-ah-sin) Apo-Indomethacin Indochron E-R Indocid Indocid Ophthalmic Suspension Indocid SR Indocin Indocin SR Indocollyre Indotec Novo-Methacin Nu-Indo Pro-Indo Rhodacine (Rx)
Indomethacin sodium trihydrate
Indomethacin sodium trihydrate (Indocin I.V.)
(in-doh- METH-ah-sin) Indocin I.V. (Rx)

Classification: Nonsteroidal anti-inflammatory drug, analgesic, antipyretic

See Also: See also Nonsteroidal Anti-Inflammatory Drugs .

Action/Kinetics: PO. Onset: 30 min for analgesia and up to 1 week for anti-inflammatory effect. Peak plasma levels: 1-2 hr (2-4 hr for sustained-release). Peak action for gout: 24-36 hr; swelling gradually disappears in 3-5 days. Peak activity for antirheumatic effect: About 4 weeks. Duration: 4-6 hr for analgesia and 1-2 weeks for anti-inflammatory effect. Therapeutic plasma levels: 10-18 mcg/mL. t 1/2: Approximately 5 hr (up to 6 hr for sustained-release). Plasma t 1/2 following IV in infants: 12-20 hr, depending on age and dose. Approximately 90% plasma protein bound. Metabolized in the liver and excreted in both the urine and feces.

Uses: Not a simple analgesic; use only for the conditions listed. Moderate to severe rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis (drug of choice). Acute gouty arthritis and acute painful shoulder (tendinitis, bursitis). IV: Pharmacologic closure of persistent patent ductus arteriosus in premature infants. Investigational: Topically to treat cystoid macular edema (0.5% and 1% drops), sunburn, primary dysmenorrhea, prophylaxis of migraine, cluster headache, polyhydramnios.

Additional Contraindications: Pregnancy and lactation. PO indomethacin in children under 14 years of age. GI lesions or history of recurrent GI lesions. IV use: GI or intracranial bleeding, thrombocytopenia, renal disease, defects of coagulation, necrotizing enterocolitis. Suppositories: Recent rectal bleeding, history of proctitis.

Special Concerns: Restrict use in children to those unresponsive to or intolerant of other anti-inflammatory agents; efficacy has not been determined in children less than 14 years of age. Geriatric clients are at greater risk of developing CNS side effects, especially confusion. Use with caution in clients with history of epilepsy, psychiatric illness, or parkinsonism and in the elderly. Use with extreme caution in the presence of existing, controlled infections.

Additional Side Effects: Reactivation of latent infections may mask signs of infection. More marked CNS manifestations than for other drugs of this group. Aggravation of depression or other psychiatric problems, epilepsy, and parkinsonism.

Additional Drug Interactions: Captopril / Captopril effect, probably R/T inhibition of prostaglandin synthesis Diflunisal / Plasma levels of indomethacin; also, possible fatal GI hemorrhage Diuretics (loop, potassium-sparing, thiazide) / May reduce antihypertensive and natriuretic action of diuretics Lisinopril / Possible lisinopril effect Prazosin / Antihypertensive drug effects

How Supplied: Indomethacin: Capsule: 25 mg, 50 mg; Capsule, Extended Release: 75 mg; Suppository: 50 mg; Suspension: 25 mg/5 mL Indomethacin sodium trihydrate: Powder for injection: 1 mg

?Capsules, Oral Suspension Moderate to severe arthritis, osteoarthritis, ankylosing spondylitis.
Adults, initial: 25 mg b.i.d.-t.i.d.; may be increased by 25-50 mg at weekly intervals, according to condition and, if tolerated, until satisfactory response is obtained. With persistent night pain or morning stiffness, a maximum of 100 mg of the total daily dose can be given at bedtime. Maximum daily dosage: 150-200 mg. In acute flares of chronic rheumatoid arthritis, the dose may need to be increased by 25-50 mg/day until the acute phase is under control.
Acute gouty arthritis.
Adults, initial: 50 mg t.i.d. until pain is tolerable; then, reduce dosage rapidly until drug is withdrawn. Pain relief usually occurs within 2-4 hr, tenderness and heat subside in 24-36 hr, and swelling disappears in 3-4 days.
Acute painful shoulder (bursitis/tendinitis).
75-150 mg/day in three to four divided doses for 1-2 weeks.
?Sustained-Release Capsules Antirheumatic, anti-inflammatory.
Adults: 75 mg, of which 25 mg is released immediately, 1-2 times/day.
?Suppositories Anti-inflammatory, antirheumatic, antigout.
Adults: 50 mg up to q.i.d. Pediatric: 1.5-2.5 mg/kg/day in three to four divided doses (up to a maximum of 4 mg/kg or 250-300 mg/day, whichever is less).
?IV Only Patent ductus arteriosus.
3 IV doses, depending on age of the infant, are given at 12-24-hr intervals. Infants less than 2 days: first dose, 0.2 mg/kg, followed by two doses of 0.1 mg/kg each; infants 2-7 days: three doses of 0.2 mg/kg each; infants more than 7 days: first dose, 0.2 mg/kg, followed by two doses of 0.25 mg/kg each. If patent ductus arteriosus reopens, a second course of one to three doses may be given. Surgery may be required if there is no response after two courses of therapy.

Indomethacin Ratings

Overall Rating:



(based on 2 reviews)



Ease of Use:


Overall Satisfaction:





Effectiveness: *

Ease of Use: ***

Overall Satisfaction: *


Jaime, Radford, Va - 05/02/2010

Many people like to say this is a safe and effective drug, but all it has done for me is give me diarrhea and cause me to lose too much weight.


Effectiveness: *****

Ease of Use: *****

Overall Satisfaction: *****


dulce, USA - 11/06/2009

Several hours after taking this drug, I experience blood as well as blood clots in my urine. I do feel it is a awesome drug though.