Guanadrel sulfate

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structure of guanadrel sulfate

dear sir , i would like to know please the structure of guanadrel sulphate thanks 
by Laila El Kaial in Egypt, 10/05/2007

guanadrel sulfate - very important

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by Laila El Kaial in Egypt, 10/05/2007

Guanadrel sulfate
Guanadrel sulfate (Hylorel)
Guanadrel sulfate
( GWON-ah-drell)
Pregnancy Category: B Hylorel (Rx)

Classification: Antihypertensive, peripherally acting antiadrenergic

See Also: See also Antihypertensive Agents .

Action/Kinetics: Similar to that of guanethidine. Inhibits vasoconstriction by blocking efferent, peripheral sympathetic pathways by depleting norepinephrine reserves and inhibiting norepinephrine release. Causes increased sensitivity to norepinephrine. Onset: 2 hr. Peak plasma levels: 1.5-2 hr. Peak effect: 4-6 hr. t 1/2: Approximately 10 hr. Duration: 4-14 hr. Excreted through the urine as unchanged drug (40%) and metabolites.

Uses: Hypertension in those not responding to a thiazide diuretic.

Contraindications: Pheochromocytoma, CHF, within 1 week of MAO drug use, within 2-3 days of elective surgery, lactation.

Special Concerns: Use with caution in bronchial asthma and peptic ulcer. Safety and efficacy not established in children. Geriatric clients may be more sensitive to the hypotensive effects.

Side Effects: CNS: Fainting, fatigue, headache, drowsiness, paresthesias, confusion, psychological problems, depression, syncope, sleep disorders, visual disturbances. CV: Chest pain, orthostatic hypotension, palpitations, peripheral edema. Respiratory: Exertional or resting SOB, coughing. GI: Increase in number of bowel movements, constipation, anorexia, indigestion, flatus, glossitis, N&V, dry mouth and throat, abdominal distress or pain. GU: Difficulty in ejaculation, impotence, nocturia, hematuria, urinary urgency or frequency. Miscellaneous: Leg cramps during both the day and night, excessive weight gain or loss, backache, neckache, joint pain or inflammation, aching limbs.

Overdose Management: Symptoms: Postural hypotension, syncope, dizziness, blurred vision. Treatment: Administration of a vasoconstrictor (e.g., phenylephrine) if hypotension persists. If used, monitor carefully as client may be hypersensitive.

Drug Interactions: Beta-adrenergic blocking agents / Excessive hypotension, bradycardia Phenothiazines / Reverses effect of guanadrel Phenylpropanolamine / Effect of guanadrel Reserpine / Excessive hypotension, bradycardia Sympathomimetics / Hypotensive effect of guanadrel may be reversed; also, guanadrel may the effects of directly acting sympathomimetics Tricyclic antidepressants / Reverses effect of guanadrel Vasodilators / Risk of orthostatic hypotension

How Supplied: Tablet: 10 mg

?Tablets Hypertension.
Individualized. Initial: 5 mg b.i.d.; then, increase dosage to maintenance level of 20-75 mg/day in two to four divided doses. With a C CR of 30-60 mL/min, use an initial dose of 5 mg q 24 hr. If the C CR is less than 30 mL/min, increase the dosing interval to q 48 hr. Make dose changes carefully q 7 or more days for moderate renal insufficiency and q 14 or more days for severe insufficiency.

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