Guanabenz acetate

Questions | Reviews ***~

This generic is very expensive

Why is this generic so costly in comparison to other more popular anti-hypertensive generics?
by Mikie Gaber in Spokane, WA, 07/25/2007

Guanabenz acetate
Guanabenz acetate (Wytensin)
Guanabenz acetate
( GWON-ah-benz)
Pregnancy Category: C Wytensin (Rx)

Classification: Antihypertensive, centrally acting antiadrenergic

See Also: See also Antihypertensive Agents .

Action/Kinetics: Stimulates alpha-2-adrenergic receptors in the CNS, resulting in a decrease in sympathetic impulses and in sympathetic tone. It also decreases the pulse rate, but postural hypotension has not been manifested. Onset: 60 min. Peak effect: 2-4 hr. Peak plasma levels: 2-5 hr. t 1/2: 6 hr. Duration: 8-12 hr.

Uses: Hypertension, alone or as adjunct with thiazide diuretics.

Contraindications: Lactation, children under 12 years of age.

Special Concerns: Use with caution in severe coronary insufficiency, cerebrovascular disease, recent MI, hepatic or renal disease. Geriatric clients may be more sensitive to the hypotensive and sedative effects; dose reduction may be necessary due to age-related decreases in renal function. Sudden cessation may result in an increase in catecholamines and, rarely, "overshoot" hypertension.

Side Effects: CNS: Drowsiness and sedation (common), dizziness, weakness, headache, ataxia, depression, disturbances in sleep, excitement. GI: Dry mouth (common), N&V, diarrhea, constipation, abdominal discomfort, epigastric pain. CV: Palpitations, chest pain, arrhythmias, AV dysfunction or block. Dermatologic: Rash, pruritus. Miscellaneous: Edema, blurred vision, muscle aches, dyspnea, nasal congestion, urinary frequency, gynecomastia, disturbances of sexual function, taste disorders, aches in extremities.

Overdose Management: Symptoms: Hypotension, sleepiness, irritability, miosis, lethargy, bradycardia. Treatment: Supportive treatment. VS and fluid balance should be monitored. Syrup of ipecac or gastric lavage followed by activated charcoal; administration of fluids, pressor agents, and atropine. Maintain an adequate airway; artificial respiration may be required.

Drug Interactions: Additive sedation with CNS depressants.

How Supplied: Tablet: 4 mg, 8 mg

?Tablets Hypertension.
Adults, initial: 4 mg b.i.d. alone or with a thiazide diuretic; then, increase by 4-8 mg/day q 1-2 weeks until control achieved. Maximum recommended dose: 32 mg b.i.d.

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