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Adult Dosage of Glyburide

What does micronized and non micronized mean in the adult dosage descriptions for glyburide? I have level 2 diabetes and take 10mg glyburide before breakfast. My glucose readings are always high in the morning, 6:30am, running at 10.2 sometimes the...
by Frank Lovelock in Ontario, Canada, 11/25/2005

Glyburide (Gen-Glybe , Glynase PresTab, Micronase)
( GLYE-byou-ryd)
Pregnancy Category: B Albert Glyburide Apo-Glyburide Diabeta Euglucon Gen-Glybe Glynase PresTab Med-Glybe Micronase Novo-Glyburide Nu-Glyburide Penta-Glyburide (Rx)

Classification: Sulfonylurea (anti-diabetic), second-generation

See Also: See also Antidiabetic Agents .

Action/Kinetics: Has a mild diuretic effect. Onset, nonmicronized: 2-4 hr; micronized: 1 hr. t 1/2, nonmicronized: 10 hr; micronized: Approximately 4 hr. Time to peak levels: 4 hr. Duration, nonmicronized: 16-24hr; micronized: 12-24 hr. Metabolized in liver to weakly active metabolites. Excreted in bile (50%) and through the kidneys (50%). Micronized glyburide, 3 mg tablets, produces serum levels that are not bioequivalent to those from nonmicronized glyburide, 5 mg tablets.

Uses: May be used with metformin when diet and glyburide or diet and metformin alone do not provide adequate control.

Additional Drug Interactions: Anticoagulants / Either or anticoagulant effect Ciprofloxacin / Potentiation of hypoglycemic effect

How Supplied: Tablet, micronized: 1.5 mg, 3 mg, 4.5 mg, 6 mg; Tablet, nonmicronized: 1.25 mg, 2.5 mg, 5 mg

?Tablets, Nonmicronized (DiaBeta/Micronase) Diabetes.
Adults, initial: 2.5-5 mg/day given with breakfast (or the first main meal); then, increase by 2.5 mg at weekly intervals to achieve the desired response. Maintenance: 1.25-20 mg/day. Clients sensitive to sulfonylureas should start with 1.25 mg/day.
?Tablets, Micronized (Glynase PresTab) Diabetes.
Adults, initial: 1.5-3 mg/day given with breakfast (or the first main meal). Those sensitive to sulfonylureas should start with 0.75 mg/day. Increase by no more than 1.5 mg at weekly intervals to achieve the desired response. Maintenance: 0.75-12 (maximum) mg/day.

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