, Glynase PresTab, Micronase)
Pregnancy Category: B
Sulfonylurea (anti-diabetic), second-generation
Has a mild diuretic effect.
Onset, nonmicronized: 2-4 hr;
micronized: 1 hr.
1/2, nonmicronized: 10 hr;
micronized: Approximately 4 hr.
Time to peak levels: 4 hr.
Duration, nonmicronized: 16-24hr;
micronized: 12-24 hr. Metabolized in liver to weakly active metabolites. Excreted in bile (50%) and through the kidneys (50%). Micronized glyburide, 3 mg tablets, produces serum levels that are not bioequivalent to those from nonmicronized glyburide, 5 mg tablets.
May be used with metformin when diet and glyburide or diet and metformin alone do not provide adequate control.
Additional Drug Interactions:
Anticoagulants / Either
Ciprofloxacin / Potentiation of hypoglycemic effect
Tablet, micronized: 1.5 mg, 3 mg, 4.5 mg, 6 mg;
Tablet, nonmicronized: 1.25 mg, 2.5 mg, 5 mg
?Tablets, Nonmicronized (DiaBeta/Micronase)
Adults, initial: 2.5-5 mg/day given with breakfast (or the first main meal);
then, increase by 2.5 mg at weekly intervals to achieve the desired response.
Maintenance: 1.25-20 mg/day. Clients sensitive to sulfonylureas should start with 1.25 mg/day.
?Tablets, Micronized (Glynase PresTab)
Adults, initial: 1.5-3 mg/day given with breakfast (or the first main meal). Those sensitive to sulfonylureas should start with 0.75 mg/day. Increase by no more than 1.5 mg at weekly intervals to achieve the desired response.
Maintenance: 0.75-12 (maximum) mg/day.