Glucagon


Questions | Reviews **~

Glucagon Injections


I have the kit and used it for the first time. The syringe that is provided has a very big needle. After the flucagon is mixed with the fluid from the syringe would it be OK to draw the mixture out with a syringe I use to insulin injections? It is muc...
by Carol M in Naples Florida, 02/06/2006

Glucagon
Glucagon
Glucagon Glucacon Diagnostic Kit Glucagon Emergency Kit (Rx)
( GLOO-kah-gon)
Pregnancy Category: B (Rx)

Classification: Insulin antagonist

Action/Kinetics: Produced by the alpha islet cells of the pancreas, glucacon accelerates liver glycogenolysis by stimulating synthesis of cyclic AMP and increasing phosphorylase kinase activity. Increased blood glucose levels result from increased breakdown of glycogen to glucose and inhibition of glycogen synthetase. Is effective only with sufficient liver glycogen. Glucagon stimulates hepatic gluconeogenesis by increasing the uptake of amino acids and converting them to glucose precursors. Also, lipolysis is increased, resulting in free fatty acids and glycerol for gluconeogenesis. Effective in overcoming hypoglycemia only if the liver has a glycogen reserve. Also relaxes smooth muscle of the GI tract and decreases gastric and pancreatic secretions; increases myocardial contractility. Glucagon for injection is of rDNA origin and is identical to human glucacon. Maximum plasma levels of glucagon: About 20 min following SC injection and about 13 min after IM injection. Peak glucose levels: 30 min after 1 mg glucagon SC and 26 min after 1 mg glucacon IM. Duration: 1-2 hr. t 1/2: 8-18 min. Metabolized in the liver, kidney, and plasma.

Uses: Treatment of severe hypoglycemia. Diagnostic aid in radiologic exams of the stomach, duodenum, small bowel, and colon where decreased intestinal motility is desired. Use only under medical supervision or in accordance with strict instructions received from the physician. Investigational: Treatment of propranolol overdose and in CV emergencies.

Contraindications: Use in pheochromocytoma.

Special Concerns: Use with caution during lactation, in clients with renal or hepatic disease, in those who are undernourished and emaciated, and in clients with a history of insulinoma. Safety and efficacy have not been determined for use in children as a diagnostic aid.

Side Effects: GI: N&V. Allergy: Respiratory distress, urticaria, hypotension. Stevens-Johnson syndrome when used as diagnostic aid.

Overdose Management: Symptoms: N&V, gastric hypotonicity, diarrhea, hypokalemia. Possible transient BP and pulse rate. Treatment: Symptomatic.

Drug Interactions: Anticoagulants, oral / Anticoagulant effects by hypoprothrombinemia Antidiabetic agents / Hyperglycemia due to glucagon antagonizes hypoglycemic drug effect Corticosteroids, Epinephrine, Estrogens, Phenytoin / Additive hyperglycemic effect of drugs listed

How Supplied: Powder for Injection: 1 mg (1 unit)

Dosage
?IM, IV, SC Severe hypoglycemia.
Adults and children > 20 kg: 1 mg (1 unit); if the response is delayed, give an additional dose of glucagon. Children < 20 kg: 0.5 mg (0.5 unit) or a dose equivalent to 20-30 mcg/kg.
Diagnostic aid for GI tract.
Dose dependent on desired onset of action and duration of effect necessary for the examination. IV: 0.25-0.5 mg (onset: 1 min; duration: 9-17 min); 2 mg (onset: 1 min; duration 22-25 min). IM: 1 mg (onset: 8-10 min; duration: 12-27 min); 2 mg (onset: 4-7 min; duration: 21-32 min). Because the stomach is less sensitive to glucagon, give 0.5 mg IV or 2 mg IM.
For colon examination.
IM: 2 mg 10 min prior to procedure.
Treatment of toxicity of beta-adrenergic blocking agents.
Adults, IV, initial: 2-3 mg given over 30 sec; may be repeated at the rate of 5 mg/hr until client is stabilized.

Glucagon Ratings

Overall Rating:

2.5**~

 

(based on 2 reviews)

Effectiveness:

****

Ease of Use:

*

Overall Satisfaction:

***

Reviewit

Reviews

Glucagon
3.0

Effectiveness: *****

Ease of Use: *

Overall Satisfaction: ***

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Emma, Emma - 01/15/2014

Extracting insulin from very fresh sheep or pig paacernses is fairly easy, if you have the required equipment, consumable supplies, and knowledge. I recall doing it in (I think) high school science labs - but we didn't actually use it. It is somewhat time consuming, as well.One US patent for extraction is number 2779706; another is 2637680.One key concept is that the very fresh pancreas needs to be kept very cold during most of the processing...if you don't have water ice to keep the process in an ice bath, you won't get good insulin. On the other hand, it has to be water ice - if the pancreas freezes the tissue is too damaged to use.The problem with this method is that a) you have to sacrifice an animal for the process (and you may not have enough to go around), b) the insulin is not as good as what people are now used to (all of which is made by bacteria genetically modified to make pure human insulin), c) animal insulin isn't the same as human insulin, varying by 1-5 aminio acids depending on the source animal. Even with real (made) human insulin, diabetics have problems, they had more problems with animal insulins. It was used decades ago but they stopped for a reason.d) using sheep or cows as sources can theoretically lead to spread of prion diseases (mad cow disease, scrapy, New variant Creuzfeld-Jakob disease).e) Bioanalysis so you know how much insulin you need (which will vary with each batch) is difficult to do and probably not realistically possible in an austere setting. Get a stronger than expected dose of insulin and you can die quickly, get a weaker than expected and you can still die, just not quickly.And then, you still need all the rest of the equipment like syringes, test strips etc, a method to keep the prepared insulin cold, and the rest.One strategy that all diabetics (insulin dependent, and non insulin dependent) is to reduce the amount of insulin they need. Loose as much weight as you possibly can, and try to avoid carbohydrates as much as possible in your diet (it's an unfortunate fact that most long-term storage foods are carbohydrate rich). Type-II (non insulin dependent) diabetics, especially, should do everything possible to get control of their condition: Exercise (as simple as a walk around the block every day), weight loss and diet control will work wonders. And Type-II diabetics on oral glycemic drugs can stockpile their drugs much more easily, of course.