Fosfomycin tromethamine

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Fosfomycin tromethamine
Fosfomycin tromethamine (Monurol)
Fosfomycin tromethamine
(fos-foh- MY-sin)
Pregnancy Category: B Monurol (Rx)

Classification: Anti-infective, antibiotic

See Also: See also Anti-Infective Agents.

Action/Kinetics: Bactericidal drug that inactivates enzyme enolpyruvyl transferase, irreversibly blocking condensation of uridine diphosphate-N-acetylglucosamine with p-enolpyruvate. This is one of first steps in bacterial wall synthesis. Also reduces adherence of bacteria to uroepithelial cells. Rapidly absorbed from GI tract and converted to fosfomycin. Maximum serum levels: 2 hr. t 1/2, elimination: 5.7 hr. Excreted unchanged in both urine and feces.

Uses: Treatment of uncomplicated urinary tract infections (acute cystitis) in women due to Escherichia coli and Enterococcus faecalis.

Contraindications: Lactation.

Special Concerns: Safety and efficacy have not been determined in children 12 years and younger.

Side Effects: GI: Diarrhea, nausea, dyspepsia, abdominal pain, abnormal stools, anorexia, constipation, dry mouth, flatulence, vomiting. CNS: Headache, dizziness, insomnia, migraine, nervousness, paresthesia, somnolence. GU: Vaginitis, dysmenorrhea, dysuria, hematuria, menstrual disorder. Respiratory: Rhinitis, pharyngitis. Miscellaneous: Asthenia, back pain, pain, rash, ear disorder, fever, flu syndrome, infection, lymphadenopathy, myalgia, pruritus, skin disorder.

Laboratory Test Alterations: ALT, AST, eosinophil count, bilirubin, alkaline phosphatase. Hematocrit, hemoglobin. or WBC, platelet count.

Drug Interactions: Metoclopramide / serum levels and urinary excretion of fosfomycin.

How Supplied: Granules for Reconstitution: 3 g

?Sachet Acute cystitis.
Women, 18 years and older: One sachet of fosfomycin mixed with water before ingesting.

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