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Flutamide dosage

My husband was diagnosed with Stage 4 prostate cancer in 1991. His treatment was Zolades (Goserelin) injections plus Eulexin, 2 caps 3x daily. He had an orchiectomy in 1993 after which dosage of Eulexin was reduced to 1 cap 3x daily. His PSA has been ...
by Leona in Clearlake Oaks, CA, 02/08/2006

Flutamide (Eulexin)
( FLOO-tah-myd)
Pregnancy Category: D Euflex Novo-Flutamide PMS-Flutamide Eulexin (Rx)

Classification: Antineoplastic, hormonal agent

See Also: See also Antineoplastic Agents .

Action/Kinetics: Acts either to inhibit uptake of androgen or to inhibit nuclear binding of androgen in target tissues. Thus, the effect of androgen is decreased in androgen-sensitive tissues. Rapidly metabolized to active (-hydroxylated derivative) and inactive metabolites in the liver and mainly excreted in the urine. t 1/2 of active metabolite: 6 hr (8 hr in geriatric clients). Ninety-four percent to 96% is bound to plasma proteins.

Uses: In combination with leuprolide acetate (i.e., a LHRH agonist) to treat stage D 2 metastatic prostatic carcinoma as well as locally confined stage B 2-C prostate cancer. In combination with goserelin acetate depots (Zoladex) to treat locally confined early stage B 2-C prostate cancer before and during radiation therapy.

Contraindications: Use during pregnancy or if basline serum ALT values exceed twice ULN.

Side Effects: Side effects are listed for treatment of flutamide with LHRH agonist. GU: Loss of libido, impotence. CV: Hot flashes, hypertension. GI: N&V, diarrhea, GI disturbances, anorexia. CNS: Confusion, depression, drowsiness, anxiety, nervousness. Hematologic: Anemia, leukopenia, thrombocytopenia, hemolytic anemia macrocytic anemia, methemoglobinemia. Hepatic: Hepatitis, cholestatic jaundice, hepatic encephalopathy, jaundice, hepatic necrosis, liver failure. Dermatologic: Rash, injection site irritation, erythema, ulceration, bullous eruptions, epidermal necrolysis. Miscellaneous: Gynecomastia, edema, neuromuscular symptoms, pulmonary symptoms, GU symptoms, malignant breast tumors.

Laboratory Test Alterations: AST, ALT, serum creatinine, SGGT, BUN, bilirubin.

Overdose Management: Symptoms: Breast tenderness, gynecomastia, increases in AST. Also possible are ataxia, anorexia, vomiting, decreased respiration, lacrimation, sedation, hypoactivity, and piloerection. Treatment: Induce vomiting if client is alert. Frequently monitor VS and observe closely.

How Supplied: Capsule: 125 mg

?Capsules Locally confined stage B 2-C and stage D 2 metastatic cancer of the prostate.
250 mg (2 capsules) t.i.d. q 8 hr for a total daily dose of 750 mg.

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