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fluconazole and ring worm

My dog is epileptic and taking Phenobarbital and Potassium Bromide to control her siezures. She recently contracted "Ring Worm" and has been prescribed Fluconazole 200mg twice daily. This dosage seems extremely high, given the animals weight of 30kg...
by Barry Gearhart in Branscomb, CA, 11/26/2005

Fluconazole (Diflucan)
(flew- KON-ah-zohl)
Pregnancy Category: C Diflucan Difulcan-150 (Rx)

Classification: Antifungal agent

Action/Kinetics: Inhibits the enzyme cytochrome P-450 in the organism, which results in a decrease in cell wall integrity and extrusion of intracellular material, leading to death. Apparently does not affect the cytochrome P-450 enzyme in animals or humans. Peak plasma levels: 1-2 hr. t 1/2: 30 hr, which allows for once daily dosing. Penetrates all body fluids at steady state. Bioavailability is not affected by agents that increase gastric pH. Eighty percent of the drug is excreted unchanged by the kidneys.

Uses: Oropharyngeal and esophageal candidiasis. Serious systemic candidal infection (including UTIs, peritonitis, and pneumonia). Cryptococcal meningitis. Maintenance therapy to prevent cryptococcal meningitis in AIDS clients. Vaginal candidiasis. To decrease the incidence of candidiasis in clients undergoing a bone marrow transplant who receive cytotoxic chemotherapy or radiation therapy. Treatment of cryptococcal meningitis and candidal infections in children.

Contraindications: Hypersensitivity to fluconazole.

Special Concerns: Use with caution during lactation and if client shows hypersensitivity to other azoles. Efficacy has not been adequately assessed in children.

Side Effects: Following single doses. GI: Nausea, abdominal pain, diarrhea, dyspepsia, taste perversion. CNS: Headache, dizziness. Other: Angioedema, anaphylaxis (rare).
Following multiple doses. Side effects are more frequently reported in HIV-infected clients than in non-HIV-infected clients. GI: N&V, abdominal pain, diarrhea, serious hepatic reactions. CNS: Headache, seizures. Dermatologic: Skin rash, exfoliative skin disorders (including Stevens-Johnson syndrome and toxic epidermal necrolysis), alopecia. Hematologic: Leukopenia, thrombocytopenia. Other: Hypercholesterolemia, hypertriglyceridemia, hypokalemia.

Laboratory Test Alterations: AST, serum transaminase (especially if used with isoniazid, oral hypoglycemic agents, phenytoin, rifampin, valproic acid).

Drug Interactions: Alfentanil / Plasma alfentanil levels Cimetidine / Fluconazole plasma levels Cisapride / Risk of serious cardiac arrhythmias Cyclosporine / Cyclosporine levels in renal transplant clients with or without impaired renal function Glipizide / Plasma glipizide levels R/T liver breakdown Glyburide / Plasma glyburide levels R/T liver breakdown Hydrochlorothiazide / Plasma fluconazole levels R/T renal clearance Phenytoin / Plasma phenytoin levels Rifampin / Plasma fluconazole levels R/T liver breakdown Theophylline / Plasma theophylline levels Tolbutamide / Plasma tolbutamide levels R/T liver breakdown Warfarin / PT Zidovudine / Plasma AZT levels Zolpidem / Zolpidem effects

How Supplied: Injection: 2 mg/mL, 200 mg/100 mL, 400 mg/200 mL; Powder for Reconstitution: 50 mg/5mL, 200 mg/5mL; Tablet: 50 mg, 100 mg, 150 mg, 200 mg

?Tablets, Oral Suspension, IV Vaginal candidiasis.
150 mg as a single oral dose.
Oropharyngeal or esophageal candidiasis.
Adults, first day: 200 mg; then, 100 mg/day for a minimum of 14 days (for oropharyngeal candidiasis) or 21 days (for esophageal candidiasis). Up to 400 mg/day may be required for esophageal candidiasis. Children, first day: 6 mg/kg; then 3 mg/kg once daily for a minimum of 14 days (for oropharyngeal candidiasis) or 21 days (for esophageal candidiasis).
Candidal UTI and peritonitis.
50-200 mg/day.
Systemic candidiasis (e.g., candidemia, disseminated candidiasis, and pneumonia).
Optimal dosage and duration in adults have not been determined although doses up to 400 mg/day have been used. Children: 6-12 mg/kg/day.
Acute cryptococcal meningitis.
Adults, first day: 400 mg; then, 200 mg/day (up to 400 mg may be required) for 10 to 12 weeks after CSF culture is negative. Children, first day: 12 mg/kg; then 6 mg/kg once daily for 10 to 12 weeks after CSF culture is negative.
Maintenance to prevent relapse of cryptococcal meningitis in AIDS clients.
Adults: 200 mg once daily. Pediatric: 6 mg/kg once daily.
Prevention of candidiasis in bone marrow transplant.
400 mg once daily. In clients expected to have severe granulocytopenia (less than 500 neutrophils/mm 3), start fluconazole several days before the anticipated onset of neutropenia and continue for 7 days after the neutrophil count rises about 1,000 cells/mm 3. In clients with renal impairment, an initial loading dose of 50-400 mg can be given; daily dose is based then on C CR.

Fluconazole Ratings

Overall Rating:



(based on 2 reviews)



Ease of Use:


Overall Satisfaction:





Effectiveness: ***

Ease of Use: *

Overall Satisfaction: *****


Rennifer, Rennifer - 03/06/2014

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Effectiveness: *

Ease of Use: **

Overall Satisfaction: ***


Patrick, Patrick - 01/13/2014

Thanks for rehnkniitg the rehnkniitg of Edwin. Glad you took the chance to explore, and that you took the feedback you got in stride.My personal lament for Edwin 2.0 was the same that I feel a lot of stories nowadays (movies, comics, tv, internets). Back story. Too much of it, that is. Creators dive into back story before they get you interested in the story (and the characters) at hand.At its best, it's an earnest effort to involve the reader/viewer/listener in the story's development. At its worst, however, it indulges the peeping-tom voyeurism that reality shows have cultivated in viewers and that money-people drool all over. To me, unveiling the back story, whether too much or too soon, sucks out the mystery that makes stories (especially those in serial format) so much fun. Anyhow, more than anything, I'm glad you put pen to page, voice to mic, and brought us Edwin's saga. If I may indulge in some back story of my own: I've spent spent a bit of time proselytizing How to Succeed in Evil since I stumbled across it in the iTunes store a few months back. My biggest success thus far was converting one of my fellow EMTs, whom you honored with a shout out in this episode. VICTORY!!!Ahem. Anyway, thanks for keeping us in stitches when we're not giving them out (a bit of poetic license stitches aren't in our state protocols). I can't wait for the next episode.