Fenofibrate

Fenofibrate is used to treat high cholesterol and high triglyceride levels. Best results come when you take this while practicing a low cholesterol diet. You should not take Fenofibrate if you have hepatitis or cirrhosis of the liver, severe kidney disease; or gallbladder disease.

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Fenofibrate
Fenofibrate (TRICOR)
Fenofibrate
( fee-noh- FY-brayt)
Pregnancy Category: C TRICOR (Rx)

Classification: Antihyperlipidemic drug

Action/Kinetics: Is converted to the active fenofibric acid, which lowers plasma triglycerides. Probable mechanism is to inhibit triglyceride synthesis, resulting in a reduction of VLDL released into the circulation, and by stimulating catabolism of triglyceride-rich lipoprotein. Also increases urinary excretion of uric acid. Well absorbed; absorption is increased when given with food. Peak plasma levels: 6-8 hr; steady-state plasma levels: within 5 days. Highly bound to plasma proteins. t 1/2: 20 hr with once daily dosing. Fenofibric acid and an inactive metabolite are excreted through the urine.

Uses: Adjunct to diet to treat Types IV and V hyperlipidemia in adults who are at risk of pancreatitis and who do not respond to diet alone.

Contraindications: Hepatic or severe renal dysfunction (including primary biliary cirrhosis), those with unexplained, persistent abnormal liver function, and preexisting gallbladder disease. Lactation.

Special Concerns: Due to similarity to clofibrate and gemfibrozil, side effects, including death, are possible. Safety and efficacy have not been determined in children.

Side Effects: GI: Pancreatitis, cholelithiasis, dyspepsia, N&V, diarrhea, abdominal pain, constipation, flatulence, eructation, hepatitis, cholecystitis, hepatomegaly. CNS: Decreased libido, dizziness, increased appetite, insomnia, paresthesia. Respiratory: Rhinitis, cough, sinusitis, allergic pulmonary alveolitis. GU: Polyuria, vaginitis. Musculoskeletal: Myopathy, myositis, arthralgia, myalgia, myasthenia, rhabdomyolysis. Hypersensitivity: Severe skin rashes, urticaria. Ophthalmic: Eye irritation, blurred vision, conjunctivitis, eye floaters. Miscellaneous: Infections, pain, headache, asthenia, fatigue, flu syndrome, arrhythmia, photosensitivity, eczema.

Laboratory Test Alterations: AST, ALT, creatinine, blood urea. Hemoglobin, uric acid.

Drug Interactions: Anticoagulants / Prolongation of PT Bile acid sequestrants / Absorption of fenofibrate due to binding Cyclosporine / Risk of nephrotoxicity HMG-CoA reductase inhibitors / Possibility of rhabdomyolysis, myopathy, and acute renal failure

How Supplied: Capsules: 67 mg

Dosage
?Capsules Hypertriglyceridemia.
Initial: 67 mg/day given with meals to optimize bioavailability. Then, individualize based on client response. Increase, if necessary, at 4- 8-week intervals. Maximuim daily dose: 201 mg/day (i.e., 3 capsules). If C CR is less than 50 mL/min, start with 67 mg/day; increase dose only after evaluation of effects on renal function and triglyceride levels. In the elderly, limit the initial dose to 67 mg/day.

Fenofibrate Ratings

Overall Rating:

3.5***~

 

(based on 2 reviews)

Effectiveness:

***

Ease of Use:

**

Overall Satisfaction:

*****

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Reviews

Fenofibrate
4.5

Effectiveness: *****

Ease of Use: ***

Overall Satisfaction: *****

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Dicko, Dicko - 01/15/2014

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