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Felodipine (Plendil)
(feh- LOHD-ih-peen)
Pregnancy Category: C Plendil Renedil (Rx)

Classification: Calcium channel blocking agent

See Also: See also Calcium Channel Blocking Agents .

Action/Kinetics: Onset after PO: 120-300 min. Peak plasma levels: 2.5-5 hr. Over 99% bound to plasma protein. t 1/2, elimination: 11-16 hr. Metabolized in the liver.

Uses: Treatment of mild to moderate hypertension, alone or with other antihypertensives.

Contraindications: Lactation.

Special Concerns: Use with caution in clients with CHF or compromised ventricular function, especially in combination with a beta-adrenergic blocking agent. Use with caution in impaired hepatic function or reduced hepatic blood flow. May cause a greater hypotensive effect in geriatric clients. Safety and effectiveness have not been determined in children.

Side Effects: CV: Significant hypotension, syncope, angina pectoris, peripheral edema, palpitations, AV block, MI, arrhythmias tachycardia. CNS: Dizziness, lightheadedness, headache, nervousness, sleepiness, irritability, anxiety, insomnia, paresthesia, depression, amnesia, paranoia, psychosis, hallucinations. Body as a whole: Asthenia, flushing, muscle cramps, pain, inflammation, warm feeling, influenza. GI: Nausea, abdominal discomfort, cramps, dyspepsia, diarrhea, constipation, vomiting, dry mouth, flatulence. Dermatologic: Rash, dermatitis, urticaria, pruritus. Respiratory: Rhinitis, rhinorrhea, pharyngitis, sinusitis, nasal and chest congestion, SOB, wheezing, dyspnea, cough, bronchitis, sneezing, respiratory infection. Miscellaneous: Anemia, gingival hyperplasia, sexual difficulties, epistaxis, back pain, facial edema, erythema, urinary frequency or urgency, dysuria.

Additional Drug Interactions: Cimetidine / Bioavailability of felodipine Digoxin / Peak plasma levels of digoxin Fentanyl / Possible severe hypotension or fluid volume Grapefruit juice / Plasma levels of felodipine R/T liver breakdown Ranitidine / Bioavailability of felodipine

How Supplied: Tablet, Extended Release: 2.5 mg, 5 mg, 10 mg

?Tablets, Extended Release Hypertension.
Initial: 5 mg once daily (2.5 mg in clients over 65 years of age and in those with impaired liver function); then: adjust dose according to response, usually at 2-week intervals with the usual dosage range being 2.5-10 mg once daily. Doses greater than 10 mg increase the rate of peripheral edema and other vasodilatory side effects.

Felodipine Ratings

Overall Rating:



(based on 3 reviews)



Ease of Use:


Overall Satisfaction:





Effectiveness: *****

Ease of Use: *****

Overall Satisfaction: ****


ginpoli, england uk - 10/04/2011

I have been taking 19 mg felodipine for two years now.I also take 10 mg rampril and 40 mg simvastin and my blood pressure has been under control for eighteen months.However my liver function test has come back elevated and i am now worried about these drugs i am taking.
I am getting retestes next week and hopefully all will be okay.I have read that in year two you can get side efeects.