Famotidine


Questions | Reviews

student, undertaking project in M Pharm Pharmaceutics


what is the absorption site for famotidine? whether it is gastric or intestinal ?famotidine criteria for the gastric retention? whether the physicochemical properties support the gastric retention criteria regarding famotidine?
by P Jeevan Reddy in Hyderabad, INDIA., 05/14/2014

student, undertaking project in M Pharm Pharmaceutics


what is the absorption site for famotidine? whether it is gastric or intestinal ? famotidine criteria for the gastric retention? whether the physicochemical properties support the gastric retention criteria regarding famotidine?
by P Jeevan Reddy in Hyderabad, INDIA., 05/14/2014

Stopping treatment


It there any discomfort caused by stopping treatment of 80mg per day suddenly? Should I cut down slowly or is it ok to just stop??
by Bonnie Froehlich in California, 09/18/2006

Famotidine
Famotidine (Pepcid)
Famotidine
(fah- MOH-tih-deen)
Pregnancy Category: B Apo-Famotidine Gen-Famotidine Novo-Famotidine Nu-Famotidine Pepcid Pepcid AC Acid Controller Pepcid IV Pepcid RPD (Rx) (Pepcid AC is OTC)

Classification: Histamine H 2 receptor antagonist

See Also: See also Histamine H 2 Antagonists .

Action/Kinetics: Competitive inhibitor of histamine H 2 receptors leading to inhibition of gastric acid secretion. Both basal and nocturnal gastric acid secretion and secretion stimulated by food or pentagastrin are inhibited. Peak plasma levels: 1-3 hr. t 1/2: 2.5-3.5 hr. Onset: 1 hr. Duration: 10-12 hr. Does not inhibit the cytochrome P-450 system in the liver; thus, drug interactions due to inhibition of liver metabolism are not expected to occur. From 25% to 30% of a PO dose is eliminated through the kidney unchanged; from 65% to 70% of an IV dose is excreted through the kidney unchanged.

Uses: Rx: Treatment of active duodenal ulcers. Maintenance therapy for duodenal ulcer, at reduced dosage, after active ulcer has healed. Pathologic hypersecretory conditions such as Zollinger-Ellison syndrome or multiple endocrine adenomas. GERD, including erosive esophagitis. Treatment of benign gastric ulcer. Investigational: Prevent aspiration pneumonitis, for prophylaxis of stress ulcers, prevent acute upper GI bleeding, as part of multidrug therapy to eradicate Helicobacter pylori.
OTC: Relief of and prevention of the symptoms of heartburn, acid indigestion, and sour stomach.

Contraindications: Cirrhosis of the liver, impaired renal or hepatic function, lactation.

Special Concerns: Safety and efficacy in children have not been established.

Side Effects: GI: Constipation, diarrhea, N&V, anorexia, dry mouth, abdominal discomfort. CNS: Dizziness, headache, paresthesias, depression, anxiety, confusion, hallucinations, insomnia, fatigue, sleepiness, agitation, grand mal seizure psychic disturbances. Skin: Rash, acne, pruritus, alopecia, urticaria, dry skin, flushing. CV: Palpitations. Musculoskeletal: Arthralgia, asthenia, musculoskeletal pain. Hematologic: Thrombocytopenia. Other: Fever, orbital edema, conjunctival injection, bronchospasm, tinnitus, taste disorders, decreased libido, impotence, pain at injection site (transient).

Drug Interactions: Antacids / Famotidine absorption from the GI tract Diazepam / Diazepam absorption from the GI tract

How Supplied: Chewable Tablet: 10 mg; Freeze-Dried Lyophilized Tablet: 20 mg, 40 mg; Injection: 10 mg/mL; Powder for Reconstitution: 40 mg/5 mL; Tablet: 10 mg, 20 mg, 40 mg

Dosage
?Oral Suspension, Tablets Duodenal ulcer, acute therapy.
Adults: 40 mg once daily at bedtime or 20 mg b.i.d. Most ulcers heal within 4 weeks and it is rarely necessary to use the full dosage for 6-8 weeks.
Duodenal ulcer, maintenance therapy.
Adults: 20 mg once daily at bedtime.
Benign gastric ulcers, acute therapy.
Adults: 40 mg at bedtime.
Hypersecretory conditions.
Adults, individualized, initial: 20 mg q 6 hr; then, adjust dose to response, although doses of up to 160 mg q 6 hr may be required for severe cases.
Gastroesophageal reflux disease.
Adults: 20 mg b.i.d. for 6 weeks. For esophagitis with erosions and ulcerations, give 20 or 40 mg b.i.d. for up to 12 weeks.
Prophylaxis of upper GI bleeding.
Adults: 20 mg b.i.d.
Prophylaxis of stress ulcers.
Adults: 40 mg/day.
Relief of and prevention of heartburn, acid indigestion, and sour stomach (OTC).
Adults and children over 12 years of age, for relief: 10 mg (1 tablet) with water. For prevention: 10 mg 1 hr before eating a meal that may cause symptoms. Maximum dose: 20 mg/24 hr. Not to be used continuously for more than 2 weeks unless medically prescribed.
?IM, IV, IV Infusion Hospitalized clients with hypersecretory conditions, duodenal ulcers, gastric ulcers; clients unable to take PO medication.
Adults: 20 mg IV q 12 hr.
Before anesthesia to prevent aspiration of gastric acid.
Adults: 40 mg IM or PO.

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