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Estazolam (ProSom)
(es- TAYZ-oh-lam)
Pregnancy Category: X ProSom (C-IV) (Rx)

Classification: Hypnotic, benzodiazepine

See Also: See also Tranquilizers, Antimanic Drugs, and Hypnotics .

Action/Kinetics: Peak plasma levels: 2 hr. t 1/2: 10-24 hr. The clearance is increased in smokers compared with nonsmokers. Metabolized in the liver and excreted mainly in the urine. Two metabolites--4′-hydroxy estazolam and 1-oxo-estazolam--have minimal pharmacologic activity although at the levels present they do not contribute significantly to the hypnotic effect.

Uses: Short-term use for insomnia characterized by difficulty in falling asleep, frequent awakenings, and/or early morning awakenings.

Contraindications: Pregnancy. Use during labor and delivery and during lactation.

Special Concerns: Use with caution in geriatric or debilitated clients, in those with impaired renal or hepatic function, in those with compromised respiratory function, and in those with depression or who show suicidal tendencies. Safety and efficacy have not been determined in children less than 18 years of age.

How Supplied: Tablet: 1 mg, 2 mg

Adults: 1 mg at bedtime (although some clients may require 2 mg). The initial dose in small or debilitated geriatric clients is 0.5 mg. Prolonged use is not recommended or necessary.

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