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Droperidol (Inapsine)
(droh- PER-ih-dol)
Pregnancy Category: C Inapsine (Rx)

Classification: Antipsychotic, butyrophenone; antianxiety agent

Action/Kinetics: Causes sedation, alpha-adrenergic blockade, peripheral vascular dilation; has antiemetic properties. For other details, see Haloperidol , and Phenothiazines . Onset (after IM, IV): 3-10 min. Peak effect: 30 min. Duration: 2-4 hr, although alteration of consciousness may last up to 12 hr. t 1/2: 2.2 hr. Metabolized in the liver and excreted in both the feces and urine.

Uses: Preoperatively; induction and maintenance of anesthesia. To relieve N&V and reduce anxiety in diagnostic procedures or surgery. Neuroleptic analgesia. Antiemetic in cancer chemotherapy (used IV).

Special Concerns: Use with caution during lactation; in the elderly, debilitated, or poor risk client; and in renal or hepatic impairment. Safety for use during labor has not been established. Safety and efficacy have not been established in children less than 2 years of age.

Side Effects: CNS: Postoperative drowsiness (common), restlessness, hyperactivity, anxiety, dizziness, postoperative hallucinations; extrapyramidal symptoms (e.g., akathisia, dystonia, oculogyric crisis). CV: Hypotension and tachycardia (common), increase in BP (when combined with fentanyl or other parenteral analgesics). Respiratory: Respiratory depression (when combined with fentanyl), laryngospasm, bronchospasm. Miscellaneous: Chills, shivering.

Drug Interactions: Anesthetics, conduction (e.g., spinal) / Peripheral vasodilation and hypotension CNS depressants / Additive or potentiating effects Narcotic analgesics / Respiratory depressant effects

How Supplied: Injection: 2.5 mg/mL

?IM Preoperatively.
Adults: 2.5-10 mg 30-60 min before surgery (modify dosage in elderly, debilitated); pediatric, 2-12 years, 88-165 mcg/kg.
Diagnostic procedures.
Adults: 2.5-10 mg 30-60 min before procedure; then, if necessary, IV, 1.25-2.5 mg.
?IV Adjunct to general anesthesia.
Adults: 0.28 mg/kg with analgesic or anesthetic; maintenance: 1.25-2.5 mg (total dose).
?IV (Slow) or IM Adjunct to regional anesthesia.
Adults: 2.5-5 mg.

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