Diphenoxylate hydrochloride with Atropine Sulfate

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Diphenoxylate hydrochloride with Atropine sulfate
Diphenoxylate hydrochloride with Atropine sulfate (Lomotil)
Diphenoxylate hydrochloride with Atropine sulfate
(dye-fen- OX-ih-layt, AH-troh-peen)
Pregnancy Category: C Lofene Logen Lomanate Lomodix Lomotil Lonox Low-Quel (C-V) (Rx)

Classification: Antidiarrheal agent, systemic

See Also: See also Cholinergic Blocking Agents .

Content: Each tablet or 5 mL of liquid contains: Antidiarrheal: Diphenoxylate HCl, 2.5 mg. Anticholinergic: Atropine sulfate, 0.025 mg.

Action/Kinetics: Chemically related to the narcotic analgesic drug meperidine but without the analgesic properties. Inhibits GI motility and has a constipating effect. May aggravate diarrhea due to organisms that penetrate the intestinal mucosa (e.g., Escherichia coli, Salmonella, Shigella) or in antibiotic-induced pseudomembranous colitis. High doses over prolonged periods may cause euphoria and physical dependence. The product also contains small amounts of atropine sulfate which will prevent abuse by deliberate overdosage. Onset: 45-60 min. t 1/2, diphenoxylate: 2.5 hr; diphenoxylic acid: 12-24 hr. Duration: 2-4 hr. Metabolized in the liver to the active diphenoxylic acid and excreted through the urine.

Uses: Symptomatic treatment of chronic and functional diarrhea. Also, diarrhea associated with gastroenteritis, irritable bowel, regional enteritis, malabsorption syndrome, ulcerative colitis, acute infections, food poisoning, postgastrectomy, and drug-induced diarrhea. Therapeutic results for control of acute diarrhea are inconsistent. Also used in the control of intestinal passage time in clients with ileostomies and colostomies.

Contraindications: Obstructive jaundice, liver disease, diarrhea associated with pseudomembranous enterocolitis after antibiotic therapy or enterotoxin-producing bacteria, children under the age of 2.

Special Concerns: Use with caution during lactation, when anticholinergics may be contraindicated, and in advanced hepatic-renal disease or abnormal renal functions. Children (especially those with Down syndrome) are susceptible to atropine toxicity. Children and geriatric clients may be more sensitive to the respiratory depressant effects of diphenoxylate. Dehydration, especially in young children, may cause a delayed diphenoxylate toxicity.

Side Effects: GI: N&V, anorexia, abdominal discomfort, paralytic ileus, megacolon. Allergic: Pruritus, angioneurotic edema swelling of gums. CNS: Dizziness, drowsiness, malaise, restlessness, headache, depression, numbness of extremities, respiratory depression, coma. Topical: Dry skin and mucous membranes, flushing. Other: Tachycardia, urinary retention, hyperthermia.

Overdose Management: Symptoms: Dry skin and mucous membranes, flushing, hyperthermia mydriasis, restlessness, tachycardia followed by miosis, lethargy, hypotonic reflexes, nystagmus, coma, severe (and possibly fatal) respiratory depression. Treatment: Gastric lavage, induce vomiting, establish a patent airway, and assist respiration. Activated charcoal (100 g) given as a slurry. IV administration of a narcotic antagonist. Administration may be repeated after 10-15 min. Observe client and readminister antagonist if respiratory depression returns.

Drug Interactions: Alcohol / Additive CNS depression Antianxiety agents / Additive CNS depression Barbiturates / Additive CNS depression MAO inhibitors / Chance of hypertensive crisis Narcotics / Effect of narcotics

How Supplied: See Content

?Oral Solution, Tablets
Adults, initial: 2.5-5 mg (of diphenoxylate) t.i.d.-q.i.d.; maintenance: 2.5 mg b.i.d.-t.i.d. Pediatric, 2-12 years: 0.3-0.4 mg/kg/day (of diphenoxylate) in divided doses.
Pediatric/Dose 2-3 years / 0.75-1.5 mg q.i.d. 3-4 years / 1-1.5 mg q.i.d. 4-5 years / 1-2 mg q.i.d. 5-6 years / 1.25-2.25 mg q.i.d. 6-9 years / 1.25-2.5 mg q.i.d. 9-12 years / 1.75-2.5 mg q.i.d.
Based on 4 mL/tsp or 2 mg of diphenoxylate. Each tablet or 5 mL of liquid preparation contains 2.5 mg diphenoxylate hydrochloride and 25 mcg of atropine sulfate. Dosage should be maintained at initial levels until symptoms are under control; then reduce to maintenance levels.

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Diphenoxylate hydrochloride with Atropine Sulfate

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Tanq, Tanq - 01/10/2014

i am having piles now What my grnamdum say was:Step 1: Buy 1 whole lotus root (fresh, when you buy that time it must be covered with mud, 1 is enough for 2 days, do not buy extra to keep)Step 2: Wash it thoroughlyStep 3: Cut it into small pieces Step 4: Pound it till u see juiceStep 5: Take out all the lotus root that had been pound and put into a bowl.Step 6: Pour water into the lotus root(not too much, jus nice when the water cover the rootStep 7: Take a cloth and pour ALL the mixture into the clothStep 8: Squeeze till dryStep 9: Pound the dry root(that had been squeeze) again, for awhileStep 10: Pour water into the root again than squeeze it till drythrow the residue awayStep 11: Put the juice into the fridge and wait for 4hrs till coldstep 12: Drink only 1 cup a day do not discontinue*This is a traditional method that had cure lots of piles' petient in my family. so do try it if u want, it reallyt helps and totally cure it. any question related to this recipe u can email mi *Once they are no more pain and swallon discontinue. usually it takes about 1 week or so