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Dimenhydrinate
Dimenhydrinate (Dramamine)
Dimenhydrinate
(dye-men-
HY-drih-nayt)
Pregnancy Category: B
Oral Liquid
Syrup
Tablets
Chewable Tablets: Apo-Dimenhydrinate
Calm-X
Dimentabs
Dramamine
Gravol
Marmine
Motion-Aid
PMS-Dimenhydrinate
Travamine
Travel Tabs
Traveltabs
Triptone
(OTC).
Injection: Dimenhydrinate Injection
Dinate
Dramanate
Dramilin
Dymenate
Gravol
Hydrate
Marmine
Reidamine
(Rx)
Classification:
Antihistamine, antiemetic
See Also:
See also
Antihistamines
[ and
Antiemetics
][.
]
Action/Kinetics:
Contains both diphenhydramine and chlorotheophylline. Antiemetic mechanism not known, but it does depress labyrinthine and vestibular function. May mask ototoxicity due to aminoglycosides. Possesses anticholinergic activity.
Duration: 3-6 hr.
Uses:
Motion sickness, especially to relieve nausea, vomiting, or dizziness. Treat vertigo.
Special Concerns:
Use of the injectable form is not recommended in neonates. Geriatric clients may be more sensitive to the usual adult dose.
How Supplied:
Chew Tablet: 50 mg;
Injection: 50 mg/mL;
Liquid: 12.5 mg/4 mL, 12.5 mg/5 mL;
Tablet: 25 mg, 50 mg
Dosage
?Elixir, Syrup, Tablets, Chewable Tablets
Motion sickness.
Adults: 50-100 mg q 4 hr, not to exceed 400 mg/day.
Pediatric, 6-12 years: 25-50 mg q 6-8 hr, not to exceed 150 mg/day;
2-6 years: 12.5-25 mg q 6-8 hr, not to exceed 75 mg/day.
?IM, IV
Adults: 50 mg as required.
Pediatric, over 2 years: 1.25 mg/kg (37.5 mg/m
2) q.i.d., not to exceed 300 mg/day.
?IV
Adults: 50 mg in 10 mL sodium chloride injection given over 2 min; may be repeated q 4 hr as needed.
Pediatric: 1.25 mg/kg (37.5 mg/m
2) in 10 mL of 0.9% sodium chloride injection given slowly over 2 min; may be repeated q 6 hr, not to exceed 300 mg/day. |
