Difenoxin hydrochloride with Atropine sulfate


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Difenoxin hydrochloride with Atropine sulfate
Difenoxin hydrochloride with Atropine sulfate (Motofen)
Difenoxin hydrochloride with Atropine sulfate
(dye-fen- OX-in, AH-troh-peen)
Pregnancy Category: C Motofen (Rx)

Classification: Antidiarrheal

See Also: See also Cholinergic Blocking Agents .

Content: Each tablet contains: Antidiarrheal: Difenoxin HCl, 1 mg. Anticholinergic: Atropine sulfate, 0.025 mg.

Action/Kinetics: Related chemically to meperidine; thus, atropine sulfate is incorporated to prevent deliberate overdosage. Difenoxin is the active metabolite of diphenoxylate and is effective at one-fifth the dosage of diphenoxylate. Slows intestinal motility by a local effect on the GI wall. Peak plasma levels: 40-60 min. The drug and its inactive metabolites are excreted through both the urine and feces.

Uses: Management of acute nonspecific diarrhea and acute worsening of episodes of chronic functional diarrhea.

Contraindications: Diarrhea caused by Escherichia coli, Salmonella or Shigella; pseudomembranous colitis caused by broad-spectrum antibiotics; jaundice; children less than 2 years of age. Hypersensitivity to difenoxin or atropine. Lactation.

Special Concerns: Use with caution in ulcerative colitis, liver and kidney disease, lactation, and in clients receiving dependence-producing drugs or in those who are addiction prone. Safety and effectiveness in children less than 12 years of age have not been determined.

Side Effects: GI: N&V, dry mouth, epigastric distress, constipation. CNS: Lightheadedness, dizziness, drowsiness, headache, tiredness, nervousness, confusion, insomnia. Ophthalmic: Blurred vision, burning eyes.

Overdose Management: Symptoms: Initially include dry skin and mucous membranes, hyperthermia, flushing, and tachycardia. These are followed by hypotonic reflexes, nystagmus, miosis, lethargy, coma, and respiratory depression (may occur up to 30 hr after overdose taken). Treatment: Naloxone may be used to treat respiratory depression.

Drug Interactions: Antianxiety agents / Potentiation or addition of CNS depressant effects Barbiturates / Potentiation or addition of CNS depressant effects Ethanol / Potentiation or addition of CNS depressant effects MAO inhibitors / Precipitation of hypertensive crisis Narcotics / Potentiation or addition of CNS depressant effects

How Supplied: See Content

Dosage
?Tablets
Adults, initial: 2 tablets (2 mg difenoxin); then, 1 tablet (1 mg difenoxin) after each loose stool or 1 tablet q 3-4 hr as needed. Total dose during a 24-hr period should not exceed 8 mg (i.e., 8 tablets).

Difenoxin hydrochloride with Atropine sulfate Ratings

Overall Rating:

3.0***

 

(based on 2 reviews)

Effectiveness:

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