Diazepam


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Side Effects of Diazepam for 2 years old


My 2 year old daughter has experience 4 convulsions due to fever. Now our pedia-neutrologist has prescribed to us to use Diazepam in 3/4 tablet (5mg) in 24 hours on the first sign of fever in order to prevent convulsion. Are there any side effects ...
by makuri in Philippines, 01/02/2006

Diazepam
Diazepam (Valium)
Diazepam
(dye- AYZ-eh-pam)
Pregnancy Category: D Apo-Diazepam Diastat Diazemuls Diazepam Intensol E Pam Novo-Dipam PMS-Diazepam Valium Valium Roche Vivol (C-IV) (Rx)

Classification: Antianxiety agent, anticonvulsant, skeletal muscle relaxant

See Also: See also Tranquilizers .

Action/Kinetics: The skeletal muscle relaxant effect of diazepam may be due to enhancement of GABA-mediated presynaptic inhibition at the spinal level as well as in the brain stem reticular formation. Onset: PO, 30-60 min; IM, 15-30 min; IV, more rapid. Peak plasma levels: PO, 0.5-2 hr; IM, 0.5-1.5; IV, 0.25 hr. Duration: 3 hr. t 1/2: 20-50 hr. Metabolized in the liver to the active metabolites desmethyldiazepam, oxazepam, and temazepam. Diazepam and metabolites are excreted through the urine. Diazepam is 97%-99% bound to plasma protein.

Uses: Anxiety, tension (more effective than chlordiazepoxide), alcohol withdrawal, muscle relaxant, adjunct to treat seizure disorders, antipanic drug. Used prior to gastroscopy and esophagoscopy, preoperatively and prior to cardioversion. In dentistry to induce sedation. Treatment of status epilepticus. Relief of skeletal muscle spasm due to inflammation of muscles or joints or trauma; spasticity caused by upper motor neuron disorders such as cerebral palsy and paraplegia; athetosis; and stiff-man syndrome. Relieve spasms of facial muscles in occlusion and temporomandibular joint disorders. IV: Status epilepticus, severe recurrent seizures, and tetanus. Rectal gel: Treat epilepsy in those with stable regimens of anticonvulsant drugs who require intermittent diazepam to control increased seizure activity. To interrupt clusters of repetitive seizures in epilepsy clients.

Additional Contraindications: Narrow-angle glaucoma, children under 6 months, lactation, and parenterally in children under 12 years.

Special Concerns: When used as an adjunct for seizure disorders, diazepam may increase the frequency or severity of clonic-tonic seizures, for which an increase in the dose of anticonvulsant medication is necessary. Safety and efficacy of parenteral diazepam have not been determined in neonates less than 30 days of age. Prolonged CNS depression has been observed in neonates, probably due to inability to biotransform diazepam into inactive metabolites.

Additional Drug Interactions: Diazepam potentiates antihypertensive effects of thiazides and other diuretics. Diazepam potentiates muscle relaxant effects of d-tubocurarine and gallamine. Fluoxetine / half-life of diazepam. Isoniazid / half-life of diazepam. Ranitidine / GI absorption of diazepam.

How Supplied: Concentrate: 5 mg/mL; Injection: 5 mg/mL; Rectal Gel: 2.5 mg, 5 mg, 10 mg, 15 mg, 20 mg; Solution: 5 mg/5 mL; Tablet 2 mg, 5 mg, 10 mg

Dosage
?Tablets, Oral Solution Antianxiety, anticonvulsant, adjunct to skeletal muscle relaxants.
Adults: 2-10 mg b.i.d.-q.i.d. Elderly, debilitated clients: 2-2.5 mg 1-2 times/day. May be gradually increased to adult level. Pediatric, over 6 months, initial: 1-2.5 mg (0.04-0.2 mg/kg or 1.17-6 mg/m 2) b.i.d.-t.i.d.
Alcohol withdrawal.
Adults: 10 mg t.i.d.-q.i.d. during the first 24 hr; then, decrease to 5 mg t.i.d.-q.i.d. as required.
Anticonvulsant.
Adults: 15-30 mg once daily.
?Rectal Gel Anticonvulsant.
Over 12 years: 0.2 mg/kg. Children, 6-11 years: 0.3 mg/kg; 2-5 years: 0.5 mg/kg. If required, a second dose can be given 4 to 12 hr after the first dose. Do not treat more than five episodes per month or more than one episode every 5 days. Adjust dose downward in elderly or debilitated clients to reduce ataxia or oversedation.
?IM, IV Preoperative or diagnostic use.
Adults: 10 mg IM 5-30 min before procedure.
Adjunct to treat skeletal muscle spasm.
Adults, initial: 5-10 mg IM or IV; then, repeat in 3-4 hr if needed (larger doses may be required for tetanus).
Moderate anxiety.
Adults: 2-5 mg IM or IV q 3-4 hr if necessary.
Severe anxiety, muscle spasm.
Adults: 5-10 mg IM or IV q 3-4 hr, if necessary.
Acute alcohol withdrawal.
Initial: 10 mg IM or IV; then, 5-10 mg q 3-4 hr.
Preoperatively.
Adults: 10 mg IM prior to surgery.
Endoscopy.
IV: 10 mg or less although doses up to 20 mg can be used; IM: 5-10 mg 30 min prior to procedure.
Cardioversion.
IV: 5-15 mg 5-10 min prior to procedure.
Tetanus in children.
IM, IV, over 1 month: 1-2 mg, repeated q 3-4 hr as necessary; 5 years and over: 5-10 mg q 3-4 hr.
?IV Status epilepticus.
Adults, initial: 5-10 mg; then, dose may be repeated at 10-15-min intervals up to a maximum dose of 30 mg. Dosage may be repeated after 2-4 hr. Children, 1 month-5 years: 0.2-0.5 mg q 2-5 min, up to maximum of 5 mg. Can be repeated in 2-4 hr. 5 years and older: 1 mg q 2-5 min up to a maximum of 10 mg; dose can be repeated in 2-4 hr, if needed.
NOTE: Elderly or debilitated clients should not receive more than 5 mg parenterally at any one time.

Diazepam Ratings

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Diazepam
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Tim, Tim - 01/14/2014

Paul, I've been sick, sorry I didn't get back to you sooner. Can you pin point what is maikng you depressed, or are you just depressed without explanation for it? I need to know so that I can give you some better advice. However, I too have suffered from depression, in the same effect, to the point that I was put on a medication called Sinequan, which was known as a tranquil medication, and all it did was make me sleep, but I felt better after a month of taking it, so if you've been on your med's for more than a month, you need to let your doctor know that it's not helping. And Paul, death is never an option. No matter what the problem, there is always another way. Nothing makes you happy, not even a million dollars? I know! But I promise, with time, it WILL pass. If you can brief me on what you think might be causing you to feel this way, I could possibly help you more. Sorry you feel so bad, but I'm here for you, and I'll keep you in my thoughts!! Cheer up, I care!!