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Action/Kinetics:
Stronger CNS effects and weaker peripheral action than amphetamine; thus, dextroamphetamine manifests fewer undesirable CV effects. After PO, completely absorbed in 3 hr.
Duration: PO, 4-24 hr;
t
1/2, adults: 10-12 hr;
children: 6-8 hr. Excreted in urine. Acidification will increase excretion, while alkalinization will decrease it.
Uses:
Attention deficit disorders in children, narcolepsy.
Additional Contraindications:
Lactation. Use for obesity.
Special Concerns:
Use of extended-release capsules for attention deficit disorders in children less than 6 years of age and the elixir or tablets for attention deficit disorders in children less than 3 years of age is not recommended. Dosage for narcolepsy has not been determined in children less than 6 years of age.
How Supplied:
Capsule, Extended Release: 5 mg, 10 mg, 15 mg;
Tablet: 5 mg, 10 mg
Dosage
?Tablets
Attention deficit disorders in children.
3-5 years, initial: 2.5 mg/day; increase by 2.5 mg/day at weekly intervals until optimum dose is achieved (usual range 0.1-0.5 mg/kg/dose each morning).
6 years and older, initial: 5 mg 1-2 times/day; increase in increments of 5 mg/week until optimum dose is achieved (rarely over 40 mg/day).
Narcolepsy.
Adults: 5-60 mg in divided doses daily.
Children over 12 years, initial: 10 mg/day; increase in increments of 10 mg/day at weekly intervals until optimum dose is reached.
Children, 6-12 years, initial: 5 mg/day; increase in increments of 5 mg/week until optimum dose is reached (maximum is 60 mg/day).
?Extended-Release Capsule
Attention deficit disorders.
Children, 6 years and older: 5-15 mg/day.
Narcolepsy.
Adults: 5-30 mg/day.
Children, 6-12 years: 5-15 mg/day;
12 years and older: 10-15 mg/day.
