Clomipramine hydrochloride

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could this med. affect my dogs liver?

  I have a Shar pei that is almost one year old. She has been on this medication for seperaton anxiety for about four months. This morning she bacame ill and I rushed her to the E.R Vet. Upon completion of her blood work her liver count was ...
by Melissa Black in Charleston, South Carolina, 10/07/2007

Clomipramine hydrochloride
Clomipramine hydrochloride (Anafranil)
Clomipramine hydrochloride
(kloh- MIP-rah-meen)
Pregnancy Category: C Anafranil Apo-Clomipramine Gen-Clomipramine Med-Clomipramine Novo-Clopamine Penta-Clomipramine (Rx)

Classification: Antidepressant, tricyclic

See Also: See also Antidepressants, Tricyclic .

Action/Kinetics: Significant anticholinergic and sedative effects as well as moderate orthostatic hypotension. Significant serotonin uptake blocking activity and moderate blocking activity for norepinephrine. t 1/2: 19-37 hr. Effective plasma levels: 80-100 ng/mL. Time to reach steady state: 7-14 days. Metabolized to the active desmethylclomipramine.

Uses: Obsessive-compulsive disorder in which the obsessions or compulsions cause marked distress, significantly interfere with social or occupational activities, or are time-consuming to meet the DSM-IV diagnosis. Panic attacks and cataplexy associated with narcolepsy.

Contraindications: To relieve symptoms of depression.

Special Concerns: Hyperthermia has occurred, usually when used with neuroleptics. Safety has not been established for use during lactation or in children less than 10 years of age.

Additional Side Effects: Hyperthermia, especially when used with other drugs. Increased risk of seizures. Aggressive reactions, asthenia, anemia, eructation, failure to ejaculate, sexual dysfunction in males, laryngitis, vestibular disorders, muscle weakness.

Laboratory Test Alterations: AST, ALT.

Drug Interactions: Possible clomipramine plasma levels when taken with St. John's wort; R/T metabolism.

How Supplied: Capsule: 25 mg, 50 mg, 75 mg

Adult, initial: 25 mg/day; then, increase gradually to approximately 100 mg during the first 2 weeks (depending on client tolerance). The dose may then be increased slowly to a maximum of 250 mg/day over the next several weeks. Adolescents, children, initial: 25 mg/day; then, increase gradually during the first 2 weeks to a maximum of 100 mg or 3 mg/kg, whichever is less. The dose may then be increased to a maximum daily dose of 3 mg/kg or 200 mg, whichever is less. Maintenance, adults and children: Adjust the dose to the lowest effective dose with periodic reassessment to determine need for continued therapy.

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