Questions | Reviews

what are the reasons for taking cilostazol?

  I take this beacuse I have numb feet and they tingle and burn, it helps some , my Dr.says it is neurotphy and I also have type two dibetes.
by Rita Keever in Casper Wyo. USA, 01/15/2009

antiplatelet action of cilostazol

I would like to read more about the antiplatelet effects of cilostazol, I do not understand why it doesn´t potentiate the effect of aspirin, clopidogrel and or warfarin? Is the antiplatelet effect mild? I would also like to know the physiologic ...
by Martin H Koretzky in Buenos Aires Argentina, 02/13/2008

Cilostazol (Pletal)
(sih- LESS-tah-zohl)
Pregnancy Category: C Pletal (Rx)

Classification: Antiplatelet drug

Action/Kinetics: Inhibits cellular phosphodiesterase (PDE), especially PDE III. Cilostazol and several metabolites inhibit cyclic AMP PDE III. Suppression of this isoenzyme causes increased levels of cyclic AMP resulting in vasodilation and inhibition of platelet aggregation. Inhibits platelet aggregation caused by thrombin, ADP, collagen, arachidonic acid, epinephrine, and shear stress. High fat meals significantly increase absorption. Significantly plasma protein bound. Extensively metabolized by the liver with two of the metabolites being active. Primarily excreted through the urine (74%) with the rest in the feces.

Uses: Reduce symptoms of intermittent claudication.

Contraindications: CHF of any severity (may cause a decreased survival rate in clients with class III-IV CHF). Concurrent use of grapefruit juice. Lactation.

Special Concerns: Safety and efficacy have not been determined in children.

Side Effects: GI: Abnormal stool, diarrhea, dyspepsia, flatulence, N&V, abdominal pain, anorexia, cholelithiasis, colitis, duodenal ulcer, duodenitis, esophageal hemorrhage, esophagitis, gastritis, gastroenteritis, gum hemorrhage, hematemesis, melena, gastric ulcer, periodontal abscess, rectal hemorrhage, stomach ulcer, tongue edema. CNS: Headache, dizziness, vertigo, anxiety, insomnia, neuralgia. CV: Palpitation, tachycardia, hypertension, angina pectoris, atrial fibrillation/flutter, cerebral infarct, cerebral ischemia, CHF, heart arrest, hemorrhage hypotension, MI, myocardial ischemia, nodal arrhythmia, postural hypotension, supraventricular tachycardia, syncope, varicose veins, vasodilation, ventricular extrasystole or ventricular tachycardia Respiratory: Rhinitis, pharyngitis, increased cough, dyspnea, bronchitis, asthma, epistaxis, hemoptysis, pneumonia, sinusitis. Musculoskeletal: Back pain, myalgia, asthenia, leg cramps, arthritis, arthralgia, bone pain, bursitis. Dermatologic: Rash, dry skin, furunculosis, skin hypertrophy, urticaria. GU: Hematuria, UTI, cystitis, urinary frequency, vaginal hemorrhage, vaginitis. Hematologic: Anemia, ecchymosis, iron deficiency anemia, polycythemia, purpura. Ophthalmic: Amblyopia, blindness, conjunctivitis, diplopia, eye hemorrhage, retinal hemorrhage. Miscellaneous: Infection, peripheral edema, hyperesthesia, paresthesia, flu syndrome, ear pain, tinnitus, chills, facial edema, fever, generalized edema, malaise, neck rigidity, pelvic pain, retroperitoneal hemorrhage diabetes mellitus.

Laboratory Test Alterations: GGT, creatinine. Albuminuria, hyperlipemia, hyperuricemia.

Overdose Management: Symptoms: Severe headache, diarrhea, hypotension, tachycardia, possible cardiac arrhythmias. Treatment: Observe client carefully and provide symptomatic treatment.

Drug Interactions: Diltiazem, erythromycin, grapefruit juice, itraconazole, ketoconazole, macrolide antibiotics, and omeprazole inhibit liver enzymes that breakdown cilostazol, resulting in plasma levels. Reduce dose of these drugs if used concomitantly.

How Supplied: Tablets: 50 mg, 100 mg

?Tablets Intermittent claudication.
100 mg b.i.d. taken 30 min or more before or 2 hr after breakfast and dinner. Consider a dose of 50 mg b.i.d. during coadministration of diltiazem, erythromycin, itraconazole, or ketoconazole.

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