Chlorthalidone


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Chlorthalidone
Chlorthalidone (Hygroton)
Chlorthalidone
(klor- THAL-ih-dohn)
Pregnancy Category: B Apo-Chlorthalidone Hygroton Novo-Thalidone Thalitone Uridon (Rx)

Classification: Diuretic, thiazide

See Also: See also Diuretics, Thiazides .

Action/Kinetics: Onset: 2-3 hr. Peak effect: 2-6 hr. Duration: 24-72 hr. t 1/2: 40 hr. Bioavailability may be dose-dependent.

Additional Uses: To potentiate and reduce dosage of other antihypertensive agents.

Special Concerns: Geriatric clients may be more sensitive to the usual adult dose.

Additional Side Effects: Exfoliative dermatitis, toxic epidermal necrolysis.

How Supplied: Tablet: 15 mg, 25 mg, 50 mg, 100 mg

Dosage
?Tablets Edema.
Adults, initial: 50-100 mg/day (30-60 mg Thalitone) or 100-200 mg (60 mg Thalitone) on alternate days. Some clients require 150 or 200 mg (90-120 mg Thalitone). Maximum daily dose: 200 mg (120 mg Thalitone). Pediatric: All uses, 2 mg/kg (60 mg/m 2) 3 times/week.
Hypertension.
Adults, initial: Single dose of 25 mg (15 mg Thalitone); if response is not sufficient, dose may be increased to 50 mg (30 mg Thalitone). For additional control, increase the dose to 100 mg/day (except Thalitone) or a second antihypertensive drug may be added to the regimen. Maintenance: Determined by client response. NOTE: Doses greater than 25 mg/day are likely to increase potassium excretion but not cause further benefit in sodium excretion or BP reduction.

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