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Chlorothiazide (Diuril)
(klor-oh- THIGH-ah-zyd)
Pregnancy Category: C Diuril (Rx)
Chlorothiazide sodium
Chlorothiazide sodium (Sodium Diuril)
(klor-oh- THIGH-ah-zyd)
Pregnancy Category: C Sodium Diuril (Rx)

Classification: Diuretic, thiazide type

See Also: See also Diuretics, Thiazides .

Action/Kinetics: Onset: 2 hr for PO, 15 min for IV; Peak effect: 4 hr for PO, 30 min for IV; Duration: 6-12 hr. t 1/2: 45-120 min. Incompletely absorbed from the GI tract. Produces a greater diuretic effect if given in divided doses.

Special Concerns: Geriatric clients may be more sensitive to the usual adult dose.

Additional Side Effects: Hypotension, renal failure, renal dysfunction, interstitial nephritis. Following IV use: Alopecia, hematuria, exfoliative dermatitis, toxic epidermal necrolysis, erythema multiforme, Stevens-Johnson syndrome.

How Supplied: Chlorothiazide: Suspension: 250 mg/5 mL; Tablet: 250 mg, 500 mg. Chlorothiazide sodium: Powder for injection: 0.5 g

?Oral Suspension, Tablets, IV Diuretic.
Adults: 0.5-2 g 1-2 times/day either PO or IV (reserved for clients unable to take PO medication or in emergencies). Some clients may respond to the drug given 3-5 days each week.
Adults, IV, PO: 0.5-1 g/day in one or more divided doses. Pediatric, 6 months and older, PO: 22 mg/kg/day (10 mg/lb/day) in two divided doses; 6 months and younger, PO: 33 mg/kg/day (15 mg/lb/day) in two divided doses. Thus, children up to 2 years of age may be given 125-375 mg/day in two doses while children 2-12 years of age may be given 375 mg-1 g/day in two doses. IV use in children is not recommended.

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