Cerivastatin sodium

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Cerivastatin sodium
Cerivastatin sodium (Baycol)
Cerivastatin sodium
(seh- RIHV-ah-stat-in)
Pregnancy Category: X Baycol (Rx)

Classification: Antihyperlipidemic, HMG-CoA reductase inhibitor

See Also: See also Antihyperlipidemic Agents--HMG-CoA Reductase Inhibitors.

Action/Kinetics: Competitive inhibitor of HMG-CoA reductase leading to inhibition of cholesterol synthesis and decrease in plasma cholesterol levels. Peak plasma levels: 2.5 hr. t 1/2, terminal: 2-3 hr. Food does not affect blood levels. Undergoes first pass metabolism. Metabolized in liver and excreted through urine and feces.

Uses: Adjunct to diet to reduce elevated total cholesterol, LDL-C, apo B and TG levels in clients with primary hypercholesterolemia and mixed dyslipidemia where hypercholesterolemia is the major finding (Fredrickson types IIa and IIb) when response to diet or other non-pharmacologic approaches have been inadequate. Treatment is important in clients at significantly high risk for atherosclerotic vascular disease due to hypercholesterolemia.

Contraindications: Use in active liver disease or unexplained elevation of serum transaminases. Pregnancy, lactation.

Special Concerns: Use in women of child-bearing age only when pregnancy is unlikely and they have been informed of potential risks. Drug has not been evaluated in rare homozygous familial hypercholesterolemia. Due to interference with cholesterol synthesis and lower cholesterol levels, may be blunting of adrenal or gonadal steroid hormone production. Use with caution in renal or hepatic insufficiency. Safety and efficacy have not been determined in children.

Side Effects: See also HMG-CoA Reductase Inhibitors. Musculoskeletal: Rarely, rhabdomyolysis with acute renal failure secondary to myoglobinemia. Also, leg pain, back pain. Respiratory: Rhinitis, cough, pharyngitis, sinusitis. Miscellaneous: Chest pain, rash, pruritus, influenza, accidental trauma, peripheral edema.

Laboratory Test Alterations: ALT, AST.

Drug Interactions: Risk of myopathy when used with azole antifungals, cyclosporine, erythromycin, fibric acid derivatives, and lipid-lowering doses of niacin.

How Supplied: Tablets: 0.2 mg, 0.3 mg, 0.4 mg

?Tablets Hyperlipidemia.
Adults: 0.4 mg once daily in evening. Recommended starting dose in those with significant renal impairment (C CR less than 60 mL/min/1.73 m 2) is 0.2 mg or 0.3 mg once daily in evening.

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Cerivastatin sodium

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Ease of Use: ***

Overall Satisfaction: ***


Alice, Alice - 01/14/2014

I agree that there is a revolving door bewteen many government organizations and big business. However, academics (who do NOT make much money, and who are NOT part of that revolving door exchange) also work on drug design. This is why it's nearly impossible to keep a drug suppressed, as many people like to believe the FDA does; if the drug existed, the pharm company that synthesized it wouldn't be the only company to know about it (or at least, to get the general idea), and even if the government were (let's assume the worst) in cahoots with big pharma to keep us all cancer-ridden, academics would reproduce the drugs and get the information out there. How can I be so sure? Because many of the drugs eventually manufactured and marketed by pharmaceutical companies were developed in whole or in part at academic institutions, and while academics will sell patents, they don't want to see their work (or the knowledge it engendered) suppressed, for a number of reasons. To believe in a conspiracy bewteen the government and big pharma that suppresses existing drugs, you have to believe in the ability of a multi-faceted organization to maintain absolute secrecy for decades. Simply doesn't happen in this day and age of information overload.