Cefadroxil monohydrate


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Cefadroxil monohydrate
Cefadroxil monohydrate (Duricef)
Cefadroxil monohydrate
(sef-ah- DROX-ill)
Pregnancy Category: B Duricef (Rx)

Classification: Cephalosporin, first-generation

See Also: See also Anti-Infectives and Cephalosporins .

Action/Kinetics: Peak serum levels: PO, 15-33 mcg/mL after 90 min. t 1/2: PO, 78-96 min. 90% excreted unchanged in urine within 24 hr.

Uses: UTIs caused by Escherichia coli, Proteus mirabilis and Klebsiella. Skin and skin structure infections due to staphylococci or streptococci. Pharyngitis and tonsillitis due to group A beta-hemolytic streptococci.

Special Concerns: Safe use in children not established. C CR determinations must be carried out in clients with renal impairment.

How Supplied: Capsule: 500 mg; Powder for Reconstitution: 125 mg/5 mL, 250 mg/5 mL, 500 mg/5 mL; Tablet: 1 g

Dosage
?Capsules, Oral Suspension, Tablets Pharyngitis, tonsillitis.
Adults: 1 g/day in single or two divided doses for 10 days. Children: 30 mg/kg/day in single or two divided doses (for beta-hemolytic streptococcoal infection, dose should be given for 10 or more days).
Skin and skin structure infections.
Adults: 1 g/day in single or two divided doses. Children: 30 mg/kg/day in divided doses q 12 hr.
UTIs.
Adults: 1-2 g/day in single or two divided doses for uncomplicated lower UTI (e.g., cystitis). For all other UTIs, the usual dose is 2 g/day in two divided doses. Children: 30 mg/kg/day in divided doses q 12 hr.
For clients with C CR rates below 50 mL/min.
Initial: 1 g; maintenance, 500 mg at following dosage intervals: q 36 hr for C CR rates of 0-10 mL/min; q 24 hr for C CR rates of 10-25 mL/min; q 12 hr for C CR rates of 25-50 mL/min.

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