Classification: Lung surfactant
Action/Kinetics: Lung surfactant which contains phospholipids, neutral lipids, and hydrophobic surfactant-associated proteins B and C from calf lungs. Calfactant modifies alveolar surface tension thus stabilizing alveoli. Adsorbs rapidly to the surface of the air:liquid interface and modifies surface tension similarly to natural lung surfactant. Treatment often rapidly improves oxygenation and lung compliance.
Uses: Prevention and treatment of respiratory distress syndrome in premature infants.
Special Concerns: For endotracheal use only. An increased proportion of clients with both intraventricular hemorrhage and periventricular leukomalacia may be seen. These were not associated with increased mortality.
Side Effects: Cyanosis, airway obstruction, bradycardia, reflux of surfactant into the endotracheal tube, requirement for manual ventilation, reintubation.
How Supplied: Suspension, intratracheal: 35 mg phospholipids/mL