Buspirone hydrochloride


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Buspirone hydrochloride
Buspirone hydrochloride (BuSpar)
Buspirone hydrochloride
(byou- SPYE-rohn)
Pregnancy Category: B Apo-Buspirone BuSpar Bustab Gen-Buspirone Linbuspirone Novo-Buspirone Nu-Buspirone PMS-Buspirone (Rx)

Classification: Nonbenzodiazepine antianxiety agent

Action/Kinetics: The mechanism of action is unknown. Not chemically related to the benzodiazepines; no anticonvulsant, muscle relaxant properties, or significant sedation has been observed. Binds to serotonin (5-HT 1A) and dopamine (D 2) receptors in the CNS; it is thus possible that dopamine-mediated neurologic disorders may occur. These include dystonia, Parkinson-like symptoms, akathisia, and tardive dyskinesia. Peak plasma levels: 1-6 ng/mL 40-90 min after a single PO dose of 20 mg. t 1/2: 2-3 hr. Extensive first-pass metabolism; active and inactive metabolites excreted in the urine and through the feces.

Uses: Anxiety disorders, short-term use to relieve symptoms of anxiety due to motor tension, apprehension, autonomic hyperactivity, or hyperattentiveness.

Contraindications: Psychoses, severe liver or kidney impairment, lactation. Not usually indicated for treatment of anxiety and tension due to stress of everyday living.

Special Concerns: Safety and efficacy in children less than 18 years of age not established. A decrease in dose may be necessary in geriatric clients due to age-related impairment of renal function.

Side Effects: CNS: Dizziness, drowsiness, insomnia, fatigue, nervousness, excitement, dream disturbances, dysphoria, noise intolerance, euphoria, depersonalization, akathisia, hallucinations, suicidal ideation, seizures, decreased concentration, confusion, anger or hostility, depression. CV: Nonspecific chest pain, hypotension, palpitations, tachycardia, syncope, hypertension. GI: N&V, diarrhea, constipation, abdominal distress, dry mouth, altered taste, increased appetite, irritable colon. Ophthalmologic: Redness and itching of eyes, conjunctivitis, photophobia, eye pain. Dermatologic: Skin rash, pruritus, dry skin, edema of face, acne, easy bruising, flushing. Neurologic: Paresthesia, tremor, numbness, incoordination. GU: Urinary hesitancy or frequency, enuresis, amenorrhea, pelvic inflammatory disease. Miscellaneous: Tinnitus, sore throat, nasal congestion, altered smell, muscle aches or pains, skin rash, headache, sweating, hyperventilation, SOB, hair loss, galactorrhea, decreased or increased libido, delayed ejaculation.

Overdose Management: Symptoms: Dizziness, drowsiness, N&V, gastric distress, miosis. Treatment: Immediate gastric lavage; general symptomatic and supportive measures.

Drug Interactions: Grapefruit juice / Plasma levels of buspirone excess sedation MAO inhibitors / BP

How Supplied: Tablet: 5 mg, 10 mg, 15 mg

Dosage
?Tablets
Adults: 5 mg t.i.d. Dosage may be increased in increments of 5 mg/day q 2-3 days to achieve optimum effects; the total daily dose should not exceed 60 mg. BuSpar is available in a 15-mg tablet that is scored in 5-mg increments and notched in 7.5-mg increments so clients can take the drug b.i.d. rather than t.i.d.

Buspirone hydrochloride Ratings

Overall Rating:

4.0****

 

(based on 2 reviews)

Effectiveness:

****

Ease of Use:

****~

Overall Satisfaction:

****

Reviewit

Reviews

Buspirone hydrochloride
4.0

Effectiveness: ****

Ease of Use: ****

Overall Satisfaction: ****

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brittany, Poway,CA - 05/11/2008

Buspirone works well to take the edge off and also works well with Luvox for anxiety, panic and depression. Because of drowsiness, I have been taking it at night and a small dose in the morning.

Buspirone hydrochloride
4.5

Effectiveness: ****

Ease of Use: *****

Overall Satisfaction: ****

Avatar_thumbnail

Nicole, Duluth, GA - 02/29/2008

I've been living with moderate anxiety for the past ten years and just recently decided to seek help for it. I was prescribed Valium about three months ago. Though I generally liked Valium, I wasn't able to function properly at work because of the drowsiness it caused. Because of this side effect, my doctor switched me to Buspirone. Today is my third day taking this medication and so far I am very pleased. I normally have intense panic attacks when I'm getting ready to leave my home, however, I'm no longer dealing with these attacks. I also no longer have hot flashes and that suffocating feeling that many people with anxiety are familiar with. I am still somewhat having feelings of anxiousness, though these feelings are nothing like I'm used to.

My only complaints about Buspirone are mild nausea, muscle jerks that only last about twenty minutes after taking the pill, and dizziness. I still favor these side effects over the drowsiness that Valium caused. I also enjoy the fact that Buspirone is not a narcotic, which means it's non habit-forming. Since this is only my third day taking the medication, I will come back within a few weeks to review Buspirone again in order to document any changes. I wish the best of luck to everyone taking Buspirone.