Brinzolamide ophthalmic suspension

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Brinzolamide ophthalmic suspension
Brinzolamide ophthalmic suspension (Azopt)
Brinzolamide ophthalmic suspension
(brin- ZOH-lah-myd)
Pregnancy Category: C Azopt (Rx)

Classification: Antiglaucoma drug

Action/Kinetics: Inhibits carbonic hydrase in the ciliary processes of the eye, thus decreasing aqueous humor production and reducing intraocular pressure (IOP). Is absorbed into the systemic circulation following ocular use. It can then distribute to RBCs. Eliminated unchanged mainly through the urine.

Uses: Treatment of elevated IOP in ocular hypertension or open-angle glaucoma.

Contraindications: Use in those with severe renal impairment (C CR less than 30 mL/min). Concomitant use with oral carbonic anhydrase inhibitors. Lactation.

Special Concerns: Is a sulfonamide; thus, similar side effects can occur. Use with caution in hepatic impairment. Safety and efficacy have not been determined in children.

Side Effects: Ophthalmic: Blurred vision following dosing, blepharitis, dry eye, foreign body sensation, hyperemia, ocular discharge, ocular discomfort, ocular keratitis, ocular pain, ocular pruritus, rhinitis, conjunctivitis, diplopia, eye fatigue, keratoconjunctivitis, keratopathy, lid margin crusting or sticky sensation, tearing, hypertonia. GI: Bitter, sour, or unusual taste; nausea, diarrhea, dry mouth, dyspepsia. CNS: Headache, dizziness. Miscellaneous: Dermatitis, allergic reactions, alopecia, chest pain, dyspnea, kidney pain, pharyngitis, urticaria.

Drug Interactions: Possible additive effects with oral carbonic anhydrase inhibitors.

How Supplied: Ophthalmic Suspension: 1%

?Ophthalmic suspension Increased intraocular pressure.
1 gtt in the affected eye(s) t.i.d.

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