Bisoprolol fumarate
Bisoprolol fumarate (Zebeta)
Bisoprolol fumarate
( BUY-soh- proh-lol)
Pregnancy Category: C Zebeta (Rx)

Classification: Beta-adrenergic blocking agent

See Also: See also Beta-Adrenergic Blocking Agents .

Action/Kinetics: Inhibits beta-1-adrenergic receptors and, at higher doses, beta-2 receptors. No intrinsic sympathomimetic activity and no membrane-stabilizing activity. t 1/2: 9-12 hr. Over 90% of PO dose is absorbed. Approximately 50% is excreted unchanged through the urine and the remainder as inactive metabolites; a small amount (less than 2%) is excreted through the feces.

Uses: Hypertension alone or in combination with other antihypertensive agents. Investigational: Angina pectoris, SVTs, PVCs.

Special Concerns: Use with caution during lactation. Safety and efficacy have not been determined in children. Since bisoprolol is selective for beta-1 receptors, it may be used with caution in clients with bronchospastic disease who do not respond to, or who cannot tolerate, other antihypertensive therapy.

Laboratory Test Alterations: AST, ALT, uric acid, creatinine, BUN, serum potassium, glucose, and phosphorus. WBCs and platelets.

How Supplied: Tablet: 5 mg, 10 mg

Dosage
?Tablets Antihypertensive.
Dose must be individualized. Adults, initial: 5 mg once daily (in some clients, 2.5 mg/day may be appropriate). Maintenance: If the 5-mg dose is inadequate, the dose may be increased to 10 mg/day and then, if needed, to 20 mg once daily. In clients with impaired renal or hepatic function, the initial daily dose should be 2.5 mg with caution used in titrating the dose upward.