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Question about medication side effects
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logan
Novice

Jan 20, 2007, 6:16 AM

Post #1 of 5 (391 views)
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Hi everyone, this is my first post. I was just diagnosed with HCM (obstructive) in the past few months at the age of 46. My doctor had me on Verapamil which made me so short of breath that I couldn't take it. He switched me to Cardizem which was working fine for me on the lowest dose but my blood pressure was still a borderline so he upped my dosage. Now, I am having terrible swelling of my legs and hands and noticing wheezing also. Now, I am also an asthmatic, but this wheezing is different from what I usually experience. How common are these side effects and what can I do about this since I can't live with this kind of swelling in my legs, it makes it difficult to walk.
Also, does anyone know if an asthmatic can safely use a beta-blocker? I know that there are some that are more selective. Does anyone have any experience with this?

Thanks for any input!



kevin
Novice

Jan 20, 2007, 11:11 AM

Post #2 of 5 (379 views)
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Welcome!

I took Cardizem for about a month last year and I'm sorry to say that it was not a very good experience for me. I had fluid problems for the first time ever while taking it, and also had my first bout with CHF. My docs at the time told me it was simply a coincidence, because after I went off of the Cardizem the fluid remained. But needless to say, I have never in my life had fluid problems of any kind prior to taking that drug. If nothing else, I believe it precipitated my going into CHF and I've had fluid trouble off and on ever since.

I know it's not a very rosy picture for me to paint, but I think all of us here on the board appreciate hearing both the bad and the good so we can make informed decisions. This is also only my personal experience with the drug. Results will vary. Unfortunately, not much research & development done in this field as rightly pointed out in a book “With a license to kill” by John Josefson ( presently available at http://www.lulu.com/content/587718 ).
Do please inform your doctor of the side-effects you are having though.


Guest
Anonymous Poster

Jan 21, 2007, 7:02 PM

Post #3 of 5 (377 views)
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Re: [logan] Question about medication side effects [In reply to] Quote | Reply

The purpose of thit reply is to convince you to visit you local Hospital Emergency Room right away. Swelling of the feet and ankles are severe side effects of Cardizem and Verapamil that you should report to your prescriber or health care professional as soon as possible.

This may be a sign of an adverse effect of Cardizem called fluid retention manifested as swollen ankles or a feeling of being bloated, weight gain, constipation, and flushing. To treat this, you may need a Diuretic, such as furosemide (Lasix) added to you treatment plan.

You must see a Physician about this fluid retension because it is a doubled-edged sword. It is one of the symptoms of HCM suggesting your current medication is not working and it is a side effect of your current medication that suggests an early warning sign of Heart Failure.

When the heart does not pump effectively, the body compensates in various ways. It starts to retain fluid and increase the volume of blood. This results in congestion of the veins, enlargement of the liver, and the accumulation of fluid in body cavities like the abdominal cavity (ascites) and in subcutaneous tissues, causing swelling (oedema) of the legs.

When there is localized retention, your doctor must determine the cause and treatment, especially since there is an underlying heart disease. Heart failure can occur at any moment, so an Emergency Physician can offer you treatment on an emergency basis until your Doctor can evaluate or determine the cause of swelling in you lower extremities.

Medical therapy is successful in the majority of patients, but for others surgery is the gold standard for relief of symptoms for patients who do not experience relief of symptoms from medications. Frequently, as a result of operation both the obstruction to ventricular outflow and the mitral regurgitation are significantly improved.

Hope this answers your question!

REFERENCE(S)

1. Better Health Channel (BHC), Fluid Retention (Online: BHC, 2006) http://www.betterhealth.vic.gov.au/bhcv2/bhcarticles.nsf/pages/Fluid_retention?OpenDocument

2. DrugDigest.org, Cardizem:What side effects may I notice from taking diltiazem?
(Online: ExpressScripts, 2006) http://www.drugdigest.org/DD/DVH/Uses/0,3915,206|Cardizem,00.html#sideEffects

3. DrugDigest.org, Verapamil:What side effects may I notice from taking verapamil?
(Online: ExpressScripts, 2006) http://www.drugdigest.org/DD/DVH/Uses/0,3915,701|Verapamil,00.html#sideEffects

4. Mayoclinic.com, Heart Disease: Cardiomyopathy (Online: Mayo Foundation for Medical Education and Research, 2006) http://www.mayoclinic.com/health/cardiomyopathy/DS00519/DSECTION=7




bkdaniels
User

Jan 21, 2007, 7:04 PM

Post #4 of 5 (374 views)
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Re: [logan] Question about medication side effects [In reply to] Quote | Reply

The purpose of this reply is to convince you to visit you local Hospital Emergency Room right away. Swelling of the feet and ankles are severe side effects of Cardizem and Verapamil that you should report to your prescriber or health care professional as soon as possible.

This may be a sign of an adverse effect of Cardizem called fluid retention manifested as swollen ankles or a feeling of being bloated, weight gain, constipation, and flushing. To treat this, you may need a Diuretic, such as furosemide (Lasix) added to you treatment plan.

You must see a Physician about this fluid retension because it is a doubled-edged sword. It is one of the symptoms of HCM suggesting your current medication is not working and it is a side effect of your current medication that suggests an early warning sign of Heart Failure.

When the heart does not pump effectively, the body compensates in various ways. It starts to retain fluid and increase the volume of blood. This results in congestion of the veins, enlargement of the liver, and the accumulation of fluid in body cavities like the abdominal cavity (ascites) and in subcutaneous tissues, causing swelling (oedema) of the legs.

When there is localized retention, your doctor must determine the cause and treatment, especially since there is an underlying heart disease. Heart failure can occur at any moment, so an Emergency Physician can offer you treatment on an emergency basis until your Doctor can evaluate or determine the cause of swelling in you lower extremities.

Medical therapy is successful in the majority of patients, but for others surgery is the gold standard for relief of symptoms for patients who do not experience relief of symptoms from medications. Frequently, as a result of operation both the obstruction to ventricular outflow and the mitral regurgitation are significantly improved.

Hope this answers your question!

REFERENCE(S)

1. Better Health Channel (BHC), Fluid Retention (Online: BHC, 2006) http://www.betterhealth.vic.gov.au/bhcv2/bhcarticles.nsf/pages/Fluid_retention?OpenDocument

2. DrugDigest.org, Cardizem:What side effects may I notice from taking diltiazem?
(Online: ExpressScripts, 2006) http://www.drugdigest.org/DD/DVH/Uses/0,3915,206|Cardizem,00.html#sideEffects

3. DrugDigest.org, Verapamil:What side effects may I notice from taking verapamil?
(Online: ExpressScripts, 2006) http://www.drugdigest.org/DD/DVH/Uses/0,3915,701|Verapamil,00.html#sideEffects

4. Mayoclinic.com, Heart Disease: Cardiomyopathy (Online: Mayo Foundation for Medical Education and Research, 2006) http://www.mayoclinic.com/health/cardiomyopathy/DS00519/DSECTION=7


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Guest
Anonymous Poster

Feb 11, 2008, 2:50 PM

Post #5 of 5 (114 views)
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Re: [logan] Question about medication side effects [In reply to] Quote | Reply

Check out www.adverse-drug-reaction.net
You can search by drug and find out what adverse events have been linked to the drugs you are taking.

You might want to think about telling your doctor or pharmacist so they can report your adverse event to the FDA

 
 
 


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