Classification:
Urinary analgesic
Action/Kinetics:
An azo dye with local analgesic and anesthetic effects on the urinary tract. Sixty-five percent excreted unchanged or as metabolites within 24 hr.
Uses:
Relief of pain, urgency or frequency, and burning in chronic UTIs or irritation, including cystitis, urethritis and pyelitis, trauma, surgery, or urinary tract instrumentation. As an adjunct to antibacterial therapy. Determine the underlying cause of the irritation.
Contraindications:
Renal insufficiency. Use in children less than 12 years of age. Chronic use to treat undiagnosed pain of the urinary tract.
Side Effects:
GI: Nausea. Hematologic: Methemoglobinemia, hemolytic anemia (especially in clients with G6PD deficiency). Dermatologic: Yellowish tinge of the skin or sclerae may indicate accumulation of drug due to renal insufficiency, pruritus, rash. Miscellaneous: Renal and hepatic toxicity, headache, anaphylactoid reaction, staining of contact lenses.
Laboratory Test Alterations:
Ehrlich's test for urine urobilinogen, phenolsulfonphthalein excretion test for kidney function, urine bilirubin, Clinistix or Tes-Tape, colorimetric laboratory test procedures (e.g., urine ketone tests, urine protein tests, urine steroid determinations).
Overdose Management:
Symptoms: Methemoglobinemia following massive overdoses. Hemolysis due to G6PD deficiency. Treatment: Methylene blue, 1-2 mg/kg IV or 100-200 mg PO of ascorbic acid to treat methemoglobinemia.
How Supplied:
Tablet: 95 mg, 97.2 mg, 100 mg, 200 mg
Dosage
•Tablets
Adults: 200 mg t.i.d. with or after meals for not more than 2 days when used together with an antibacterial agent for UTI. Pediatric, 6-12 years: 4 mg/kg t.i.d. with food for 2 days.
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