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Oxacillin sodium
Oxacillin sodium (Bactocill)
Oxacillin sodium
(ox-ah-SILL-in)
Pregnancy Category: B Bactocill (Rx)

Classification: Antibiotic, penicillin

See Also: See also Anti-Infectives and Penicillins.

Action/Kinetics: Penicillinase-resistant, acid-stable drug used for resistant staphylococcal infections. Peak plasma levels: PO, 1.6-10 mcg after 30-60 min; IM, 5-11 mcg/mL after 30 min. t1/2: 30 min.

Uses: Infections caused by penicillinase-producing staphylococci; may be used to initiate therapy when a staphylococcal infection is suspected.

How Supplied: Capsule: 250 mg, 500 mg; Injection: 1 g/50 mL, 2 g/50 mL; Powder for injection: 500 mg, 1 g, 2 g, 10 g; Powder for reconstitution: 250 mg/5 mL

Dosage
•Capsules, Oral Solution Mild to moderate infections of the upper respiratory tract, skin, soft tissue.
Adults and children (over 20 kg): 500 mg q 4-6 hr for at least 5 days. Children less than 20 kg: 50 mg/kg/day in equally divided doses q 6 hr for at least 5 days.
Septicemia, deep-seated infections.
Parenteral therapy (see below) followed by PO therapy. Adults: 1 g q 4-6 hr; children: 100 mg/kg/day in equally divided doses q 4-6 hr.
•IM, IV Mild to moderate infections.
Adults and children over 40 kg: 250-500 mg q 4-6 hr. Children less than 40 kg: 50 mg/kg/day in equally divided doses q 6 hr.
Severe infections of the lower respiratory tract or disseminated infections.
Adults and children over 40 kg: 1 g q 4-6 hr. Children less than 40 kg: 100 mg/kg/day in equally divided doses q 4-6 hr. Neonates and premature infants, less than 2,000 g: 50 mg/kg/day divided q 12 hr if less than 7 days of age and 100 mg/kg/day divided q 8 hr if more than 7 days of age. Neonates and premature infants, more than 2,000 g: 75 mg/kg/day divided q 8 hr if less than 7 days of age and 150 mg/kg/day divided q 6 hr if more than 7 days of age. Maximum daily dose: Adults, 12 g; children, 100-300 mg/kg.