[.
]Action/Kinetics:
Onset: 1-2 weeks after multiple doses. Peak levels: 2 hr. Duration: Up to 8 weeks with multiple doses. t1/2: 14 hr. Nearly 100% is absorbed from the GI tract. Excreted through the kidneys (70% with 7% unchanged) and the GI tract (23%).
Uses:
Alone or in combination with other drugs for treatment of hypertension. Edema in CHF.
Special Concerns:
Dosage has not been established in children. Geriatric clients may be more sensitive to the hypotensive and electrolyte effects.
How Supplied:
Tablet: 1.25 mg, 2.5 mg
Dosage
•Tablets
Edema of CHF.
Adults: 2.5 mg as a single dose in the morning. If necessary, may be increased to 5 mg/day after 1 week.
Hypertension.
Adults: 1.25 mg as a single dose in the morning. If the response is not satisfactory after 4 weeks, the dose may be increased to 2.5 mg taken once daily. If the response to 2.5 mg is not satisfactory after 4 weeks, the dose may be increased to 5 mg taken once daily (however, consideration should be given to adding another antihypertensive).
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