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Ibuprofen
Ibuprofen (Motrin, Advil, Nuprin)
Ibuprofen
(eye-byou-PROH-fen)
Pregnancy Category: B (first two trimesters), D (third trimester) Rx: Actiprofen Alti-Ibuprofen Apo-Ibuprofen Children's Advil Children's Motrin IBU Ibuprohm Motrin Novo-Profen Nu-Ibuprofen Saleto-400, -600, and -800. OTC: Advil Caplets, Chewable Tablets, and Tablets Bayer Select Pain Relief Formula Caplets Children's Advil Suspension Children's Motrin Liquid Suspension Children's Motrin Drops Genpril Caplets and Tablets Haltran Ibuprin Ibuprohm Caplets and Tablets Junior Strength Motrin Caplets Menadol Midol IB Motrin-IB Caplets and Tablets Nuprin Caplets and Tablets PediaCare Fever Drops Saleto-200

Classification: Nonsteroidal anti-inflammatory drug (NSAID)

See Also: See also Nonsteroidal Anti-Inflammatory Drugs.

Action/Kinetics: Time to peak levels: 1-2 hr. Onset: 30 min for analgesia and approximately 1 week for anti-inflammatory effect. Peak serum levels: 1-2 hr. t1/2: 2 hr. Duration: 4-6 hr for analgesia and 1-2 weeks for anti-inflammatory effect. Food delays absorption rate but not total amount of drug absorbed.

Uses: Rx: Analgesic for mild to moderate pain. Primary dysmenorrhea, rheumatoid arthritis, osteoarthritis, antipyretic. Investigational: Resistant acne vulgaris (with tetracyclines); inflammation due to ultraviolet-B exposure (sunburn), juvenile rheumatoid arthritis. High doses to treat progressive lung deterioration in cystic fibrosis. OTC: Relief of fever and minor aches and pains due to colds, flu, sore throats, headaches, and toothaches.

Contraindications: Pregnancy, especially during the last trimester.

Special Concerns: Individualize dosage for children less than 12 years of age as safety and effectiveness have not been established. May cause stomach bleeding in individuals who consume large amounts of alcohol regularly.

Additional Side Effects: Dermatitis (maculopapular type), rash. Hypersensitivity reaction consisting of abdominal pain, fever, headache, meningitis N&V;, signs of liver damage; especially seen in clients with SLE.

Additional Drug Interactions: Furosemide / Diuretic effect R/T renal prostaglandin synthesis Lithium / Plasma lithium levels Thiazide diuretics / See furosemide

How Supplied: Chew Tablet: 50 mg, 100 mg; Suspension: 50 mg/1.25 mL, 100 mg/5 mL; Tablet: 50 mg, 100 mg, 200 mg, 300 mg, 400 mg, 600 mg, 800 mg

Dosage
•Suspension, Chewable Tablets, Tablets Rheumatoid arthritis, osteoarthritis.
Either 300 mg q.i.d. or 400, 600, or 800 mg t.i.d.-q.i.d.; adjust dosage according to client response. Full therapeutic response may not be noted for 2 or more weeks.
Juvenile arthritis.
30-70 mg/kg/day in three to four divided doses (20 mg/kg/day may be adequate for mild cases).
Mild to moderate pain.
Adults: 400 mg q 4-6 hr, as needed.
Antipyretic.
Pediatric, 2-12 years of age: 5 mg/kg if baseline temperature is 102.5°F (39.1°C) or below or 10 mg/kg if baseline temperature is greater than 102.5°F (39.1°C). Maximum daily dose: 40 mg/kg.
Primary dysmenorrhea.
Adults: 400 mg q 4 hr, as needed.
•Tablets for OTC Use Mild to moderate pain, antipyretic, dysmenorrhea.
200 mg q 4-6 hr; dose may be increased to 400 mg if pain or fever persist. Dose should not exceed 1,200 mg/day.
•Suspension for OTC Use Pain, fever.
Children, 2-11 years: 7.5 mg/kg, up to q.i.d., to a maximum of 30 mg/kg/day.