[.
]Action/Kinetics:
Also has mild diuretic effects. Onset: 1- 3 hr. t1/2: 2-4 hr. Duration: 10-24 hr. Metabolized in liver to inactive metabolites, which are excreted through the kidneys.
Uses:
Adjunct to diet for control of hyperglycemia in clients with non-insulin-dependent diabetes.
Additional Drug Interactions:
Cimetidine may 
effect of glipizide due to 
breakdown by liver.
How Supplied:
Tablet: 5 mg, 10 mg; Tablet, Extended Release: 5 mg, 10 mg
Dosage
•Tablets, Immediate Release
Diabetes.
Adults, initial: 5 mg 30 min before breakfast; then, adjust dosage by 2.5-5 mg every few days, depending on the blood glucose response, until adequate control is achieved. Maintenance: 15-40 mg/day. Older clients should begin with 2.5 mg.
•Tablets, Extended Release
Diabetes.
Adults, initial: 5 mg with breakfast. Monitor response to therapy by measuring HbA1c at 3-month intervals. Dose can be increased to 10 mg if response is inadequate. Maintenance: 5 or 10 mg once daily; some may require 20 mg/day (maximum).
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