|
Felodipine
Felodipine (Plendil)
Felodipine
(feh-
LOHD-ih-peen)
Pregnancy Category: C
Plendil
Renedil
(Rx)
Classification:
Calcium channel blocking agent
See Also:
See also
Calcium Channel Blocking Agents
[.
]
Action/Kinetics:
Onset after PO: 120-300 min.
Peak plasma levels: 2.5-5 hr. Over 99% bound to plasma protein.
t
1/2, elimination: 11-16 hr. Metabolized in the liver.
Uses:
Treatment of mild to moderate hypertension, alone or with other antihypertensives.
Contraindications:
Lactation.
Special Concerns:
Use with caution in clients with CHF or compromised ventricular function, especially in combination with a beta-adrenergic blocking agent. Use with caution in impaired hepatic function or reduced hepatic blood flow. May cause a greater hypotensive effect in geriatric clients. Safety and effectiveness have not been determined in children.
Side Effects:
CV: Significant hypotension, syncope, angina pectoris, peripheral edema, palpitations, AV block,
MI, arrhythmias tachycardia.
CNS: Dizziness, lightheadedness, headache, nervousness, sleepiness, irritability, anxiety, insomnia, paresthesia, depression, amnesia, paranoia, psychosis, hallucinations.
Body as a whole: Asthenia, flushing, muscle cramps, pain, inflammation, warm feeling, influenza.
GI: Nausea, abdominal discomfort, cramps, dyspepsia, diarrhea, constipation, vomiting, dry mouth, flatulence.
Dermatologic: Rash, dermatitis, urticaria, pruritus.
Respiratory: Rhinitis, rhinorrhea, pharyngitis, sinusitis, nasal and chest congestion, SOB, wheezing, dyspnea, cough, bronchitis, sneezing, respiratory infection.
Miscellaneous: Anemia, gingival hyperplasia, sexual difficulties, epistaxis, back pain, facial edema, erythema, urinary frequency or urgency, dysuria.
Additional Drug Interactions:
-
Cimetidine /
 Bioavailability of felodipine
-
Digoxin /
Peak plasma levels of digoxin
-
Fentanyl / Possible severe hypotension or
fluid volume
-
Grapefruit juice /
Plasma levels of felodipine R/T
 liver breakdown
-
Ranitidine /
Bioavailability of felodipine
How Supplied:
Tablet, Extended Release: 2.5 mg, 5 mg, 10 mg
Dosage
?Tablets, Extended Release
Hypertension.
Initial: 5 mg once daily (2.5 mg in clients over 65 years of age and in those with impaired liver function);
then: adjust dose according to response, usually at 2-week intervals with the usual dosage range being 2.5-10 mg once daily. Doses greater than 10 mg increase the rate of peripheral edema and other vasodilatory side effects. |
