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Ethosuximide Questions
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Ethosuximide
Ethosuximide (Zarontin)
Ethosuximide
(eth-oh-
SUCKS-ih-myd)
Zarontin
(Rx)
Classification:
Anticonvulsant, succinimide type
See Also:
See also
Anticonvulsants
[ and
Succinimides
][.
]
Action/Kinetics:
Peak serum levels: 3-7 hr.
t
1/2, adults: 40-60 hr;
t
1/2, children: 30 hr. Steady serum levels reached in 7-10 days.
Therapeutic serum levels: 40-100 mcg/mL. Not bound to plasma protein. Metabolized in the liver. Both inactive metabolites and unchanged drug are excreted in the urine.
Uses:
Absence (petit mal) seizures.
Additional Drug Interactions:
Both isoniazid and valproic acid may
 the effects of ethosuximide.
How Supplied:
Capsule: 250 mg;
Syrup: 250 mg/5 mL
Dosage
?Capsules, Syrup
Absence seizures.
Adults and children over 6 years, initial: 250 mg b.i.d.; the dose may be increased by 250 mg/day at 4-7-day intervals until seizures are controlled or until total daily dose reaches 1.5 g.
Children under 6 years, initial: 250 mg/day; dosage may be increased by 250 mg/day every 4-7 days until control is established or total daily dose reaches 1 g. |
