Benztropine mesylate
Benztropine mesylate (Cogentin)
Benztropine mesylate
( BENS-troh-peen)
Pregnancy Category: C Apo-Benztropine Benzylate Cogentin PMS-Benztropine (Rx)

Classification: Synthetic anticholinergic, antiparkinson agent

See Also: See also Cholinergic Blocking Agents .

Action/Kinetics: Synthetic anticholinergic possessing antihistamine and local anesthetic properties. Onset, PO: 1-2 hr; IM, IV: Within a few minutes. Effects are cumulative; is long-acting (24 hr). Full effects: 2-3 days. Low incidence of side effects.

Uses: Adjunct in the treatment of parkinsonism (all types). To reduce severity of extrapyramidal effects in phenothiazine or other antipsychotic drug therapy (not effective in tardive dyskinesia).

Contraindications: Use in children under 3 years of age.

Special Concerns: Geriatric and emaciated clients cannot tolerate large doses. Certain drug-induced extrapyramidal symptoms may not respond to benztropine.

How Supplied: Injection: 1 mg/mL; Tablet: 0.5 mg, 1 mg, 2 mg

Dosage
?Tablets Parkinsonism.
Adults: 1-2 mg/day (range: 0.5-6 mg/day).
Idiopathic parkinsonism.
Adults, initial: 0.5-1 mg/day, increased gradually to 4-6 mg/day, if necessary.
Postencephalitic parkinsonism.
Adults: 2 mg/day in one or more doses.
Drug-induced extrapyramidal effects.
Adults: 1-4 mg 1-2 times/day.
?IM, IV (Rarely) Acute dystonic reactions.
Adults, initial: 1-2 mg; then, 1-2 mg PO b.i.d. usually prevents recurrence. Clients can rarely tolerate full dosage.